INT29094

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 12.65
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cleavage 3
livers 2
plasma 1
erythrocytes 1
MCF-7 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 99.52 Very High Very High Very High
chemokine 9 97.68 Very High Very High Very High
Inflammation 245 96.44 Very High Very High Very High
Pain 64 94.40 High High
Opioid 4 93.24 High High
palliative 39 87.32 High High
Substantia nigra 18 77.20 Quite High
Inflammatory response 41 60.80 Quite High
Osteoarthritis 25 53.84 Quite High
Cervicogenic headache 19 49.56 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 12 100.00 Very High Very High Very High
Flavivirus Infection 80 99.58 Very High Very High Very High
INFLAMMATION 287 99.28 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 3 97.48 Very High Very High Very High
Disease 458 97.20 Very High Very High Very High
Sprains And Strains 55 96.92 Very High Very High Very High
Hemolytic Anemia 13 96.76 Very High Very High Very High
Abscess 35 95.68 Very High Very High Very High
Neuroblastoma 10 95.52 Very High Very High Very High
Pain 58 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma concentrations of Bb, C4d, and C3a were measured as well as C3 bound to erythrocytes.
C3 Binding (bound) of in erythrocytes
1) Confidence 0.37 Published 1995 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 7554454 Disease Relevance 0.68 Pain Relevance 0.62
These findings can be interpreted to indicate that the mode of receptor binding of H-Tyr-D-Orn-Phe-Asp-NH2 is identical with that of dermorphin, but differs from that of beta-casomorphins.
Asp Binding (binding) of
2) Confidence 0.35 Published 1987 Journal J. Med. Chem. Section Abstract Doc Link 2822930 Disease Relevance 0 Pain Relevance 0.31
IgM, IgA, C3, and C4 plasma concentrations did not exhibit any consistent association with TCDD levels.
C3 Binding (association) of in plasma
3) Confidence 0.30 Published 2002 Journal Environ Health Perspect Section Abstract Doc Link PMC1241102 Disease Relevance 0.45 Pain Relevance 0.15
Thus, taking into account these considerations, the aim of this current study was to evaluate the in situ binding of antibodies, C3 and C9 complement components on trophozoites in livers of hamsters infected with E. histolytica or E. dispar and to correlate these parameters with the extension of the hepatic lesions and with trophozoites number observed in these animals in different time points.
C3 Binding (binding) of in livers
4) Confidence 0.27 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2861030 Disease Relevance 0.51 Pain Relevance 0.04
Antibodies, C3 and C9 binding to trophozoites were detected by immunohistochemistry.
C3 Binding (binding) of
5) Confidence 0.27 Published 2010 Journal Parasit Vectors Section Abstract Doc Link PMC2861030 Disease Relevance 0.55 Pain Relevance 0
In this study we evaluated the in situ binding of antibodies, C3 and C9 complement components on trophozoites, in livers of hamsters infected with E. histolytica or E. dispar.
C3 Binding (binding) of in livers
6) Confidence 0.27 Published 2010 Journal Parasit Vectors Section Abstract Doc Link PMC2861030 Disease Relevance 0.58 Pain Relevance 0
Patients with DHF had lower levels of complement factor 3 (C3; p?
C3 Binding (complement factor 3) of associated with flavivirus infection
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2728508 Disease Relevance 1.10 Pain Relevance 0
DAT reactivity in our patient was 4+ to polyspecific, 4+ to IgG and negative to C3.
C3 Binding (negative) of
8) Confidence 0.25 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546413 Disease Relevance 1.01 Pain Relevance 0
It winds around the lateral aspect and then the posterior aspect of the C2-C3 zygapophyseal joint.
C3 Binding (winds) of in posterior
9) Confidence 0.24 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693602 Disease Relevance 0.05 Pain Relevance 0.05
EGF motifs have six conserved cysteine residues that form three disulfide bonds¬óbetween C1 and C3, C2 and C4, C5 and C6.
C3 Binding (bonds) of
10) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443751 Disease Relevance 0.29 Pain Relevance 0
The genes for complement C3 and IP-10 (IFN-induced protein of 10 kDa), a non-ELR CXC chemokine, were among the genes upregulated by IL-4 in the monkey lung.
C3 Binding (complement) of in lung associated with chemokine
11) Confidence 0.20 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0 Pain Relevance 0.05
The alignment with complement receptor 1 (CR1) has functional consequences, as glycoprotein C of the virus acts as a CR1 mimic, binding to other complement components (C3 and its derivatives) blocking the complement cascades and preventing formation of the membrane attack complex [12, 13].
C3 Binding (binding) of
12) Confidence 0.16 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 0.71 Pain Relevance 0.03
The antibody used to detect iC3b in this study is iC3b-specific and does not recognize the native complement protein C3 from which iC3b is generated. iC3b staining of melanized neurons is therefore evidence for early complement activation, i.e., cleavage of C3, on these cells. iC3b and its active form, C3b, are opsonins, promoting phagocytosis of foreign antigens and cell debris.
C3 Neg (not) Binding (recognize) of in cleavage
13) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.40 Pain Relevance 0.10
At multivariate analysis, a combination of anti-C1q, C3, and C4 provided the best performance for predicting renal flares.
C3 Binding (combination) of
14) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 0.98 Pain Relevance 0
Overall, these results show that I. ricinus IxAC proteins inhibit the formation of the C3 convertase complex by interacting specifically with properdin.
C3 Binding (formation) of
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
They did not bind to C3, C3b, fB or fD (Figure 7A).
C3 Neg (not) Binding (bind) of
16) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Our study of this action mechanism showed that IxAC molecules bind specifically to properdin, preventing its association with C3 and thereby reducing formation of C3 convertase complex to levels observed in the absence of properdin.
C3 Binding (formation) of
17) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.05 Pain Relevance 0
IxAC proteins inhibit the formation of the C3 convertase complex by interacting with properdin
C3 Neg (inhibit) Binding (formation) of
18) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Biologic marker assessments included CD20+ B cells and CD138+ plasmacytoid cells, anti-dsDNA antibodies, ANAs, immunoglobulins (IgG, IgM, IgE, and IgA), and complement (C3 and C4).
C3 Binding (complement) of in B cells
19) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.36 Pain Relevance 0
Nevertheless, they did not displace bound C3 or Bb as the measured amounts of bound factors did not drop (Figure 9).
C3 Binding (bound) of
20) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0

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