INT2910

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Context Info
Confidence 0.62
First Reported 1978
Last Reported 2010
Negated 48
Speculated 17
Reported most in Abstract
Documents 169
Total Number 187
Disease Relevance 36.95
Pain Relevance 153.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
brain 12
neurons 9
spinal cord 7
substantia nigra 6
nucleus accumbens 5
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 2924 100.00 Very High Very High Very High
Glutamate 740 100.00 Very High Very High Very High
Dopamine 515 100.00 Very High Very High Very High
agonist 467 100.00 Very High Very High Very High
antagonist 424 100.00 Very High Very High Very High
Gabapentin 291 100.00 Very High Very High Very High
Neurotransmitter 290 100.00 Very High Very High Very High
Morphine 104 100.00 Very High Very High Very High
Enkephalin 91 100.00 Very High Very High Very High
GABA receptor 72 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 369 100.00 Very High Very High Very High
Convulsion 251 100.00 Very High Very High Very High
Pain 163 100.00 Very High Very High Very High
Generalized Anxiety Disorder 31 100.00 Very High Very High Very High
Hypotension 10 99.98 Very High Very High Very High
Aggression 35 99.92 Very High Very High Very High
Diabetes Mellitus 97 99.84 Very High Very High Very High
Aging 20 99.84 Very High Very High Very High
Epilepsy 177 99.64 Very High Very High Very High
Stress 268 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate ethanol consistently blunts postnatal GABA(A) receptor up-regulation across early postnatal binge-type ethanol exposure models and may increase positive modulation of GABA(A) receptors by endogenous neurosteroids.
Regulation (modulation) of GABA associated with gaba
1) Confidence 0.62 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557091 Disease Relevance 0 Pain Relevance 0.41
The addition of procaine, lidocaine, cocaine, or tetracaine did not alter either glutamic acid decarboxylase (GAD) activity or GABA transaminase (GABA-T) activity in vitro.
Neg (not) Regulation (alter) of GABA transaminase associated with gaba, generalized anxiety disorder, lidocaine and cocaine
2) Confidence 0.61 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6859579 Disease Relevance 0.25 Pain Relevance 0.92
GABA levels sampled were sensitive to nipecotic acid and calcium infusion.
Regulation (sensitive) of GABA associated with gaba
3) Confidence 0.54 Published 2009 Journal J Pain Section Abstract Doc Link 19729347 Disease Relevance 1.53 Pain Relevance 1.20
Differential regulation of GABA B receptor subunit expression and function.
Regulation (regulation) of GABA associated with gaba
4) Confidence 0.51 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12649368 Disease Relevance 0.14 Pain Relevance 0.83
However, lidocaine at concentrations lower than 1 mmol/L did not significantly affect GABA- or aspartate-induced currents.
Neg (not) Regulation (affect) of GABA
5) Confidence 0.48 Published 2008 Journal Acta Pharmacol. Sin. Section Body Doc Link 19026159 Disease Relevance 0.06 Pain Relevance 0
The effects of midazolam, a water-soluble benzodiazepine, on GABA disposal (14CO2 from [1-14C]GABA) and on the individual processes of GABA uptake, GABA release, and GABA-transaminase in the rat brain synaptosomal model system were studied.
Regulation (effects) of GABA-transaminase in brain associated with gaba and versed
6) Confidence 0.45 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7247056 Disease Relevance 0 Pain Relevance 0.75
The role of specific dopamine receptor subtypes in the regulation of GABA release in the substantia nigra was investigated using microdialysis in the awake rat.
Regulation (regulation) of GABA in substantia nigra associated with gaba, substantia nigra and dopamine receptor
7) Confidence 0.45 Published 1999 Journal Synapse Section Abstract Doc Link 10188635 Disease Relevance 0 Pain Relevance 0.77
The addition of procaine, lidocaine, cocaine, or tetracaine did not alter either glutamic acid decarboxylase (GAD) activity or GABA transaminase (GABA-T) activity in vitro.
Neg (not) Regulation (alter) of GABA associated with gaba, generalized anxiety disorder, lidocaine and cocaine
8) Confidence 0.44 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6859579 Disease Relevance 0.25 Pain Relevance 0.93
The findings suggest that Enk and GABA are released from the same or convergent terminals and co-regulate the activity of common target neurons within the rat VTA.
Regulation (co-regulate) of GABA in neurons associated with ventral tegmentum, gaba and enkephalin
9) Confidence 0.43 Published 1995 Journal Brain Res. Section Abstract Doc Link 7538419 Disease Relevance 0.09 Pain Relevance 0.87
The GABA-B receptor antagonist CGP 35348 (50 microM) did not affect GABA levels when infused locally in the ventromedial thalamus and neither affected the response in neuronal GABA after stimulation.
Neg (not) Regulation (affect) of GABA in neuronal associated with gaba, ventromedial thalamus and antagonist
10) Confidence 0.43 Published 1997 Journal Synapse Section Abstract Doc Link 9097406 Disease Relevance 0 Pain Relevance 1.11
The GABA-A antagonist bicucilline (50 microM) was ineffective when infused locally in the ventromedial thalamus, but prolonged the increase in neuronal GABA release after nigral stimulation; the GABA levels were increased during two 3-min samples to approximately 165%, indicating a functional role for GABA-A receptors in regulating the release of GABA from nigrothalamic GABAergic neurons.
Regulation (regulating) of GABA in GABAergic neurons associated with gaba, ventromedial thalamus, gabaergic and antagonist
11) Confidence 0.43 Published 1997 Journal Synapse Section Abstract Doc Link 9097406 Disease Relevance 0 Pain Relevance 1.17
The regulation of GABA(B) eIPSPs or the interneurons that produce them are not well understood.
Regulation (regulation) of GABA in interneurons associated with gaba
12) Confidence 0.43 Published 2008 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 18097653 Disease Relevance 0 Pain Relevance 0.51
However, gamma-aminobutyric acid (GABA) has also been hypothesized to play a role in the effect of SCS, but there have been no studies of the possible effects of SCS on GABA release.
Spec (possible) Regulation (effects) of GABA associated with gaba and spinal-cord stimulation
13) Confidence 0.43 Published 1994 Journal Neurosurgery Section Abstract Doc Link 8190224 Disease Relevance 0.15 Pain Relevance 0.95
Using an animal model of neuropathic pain, behavioral and biochemical experiments were performed to assess the effects of this condition on pain threshold and GABA(B) receptor sensitivity and subunit gene expression in the rat lumbar spinal cord.
Regulation (effects) of GABA in spinal cord associated with gaba, pain threshold, neuropathic pain and spinal cord
14) Confidence 0.42 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.56 Pain Relevance 1.03
The present study was designed to test whether propofol, which like benzodiazepines acts on GABA(A) receptors, displays similar interactions with opioids.
Regulation (acts) of GABA associated with gaba and opioid
15) Confidence 0.41 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9224789 Disease Relevance 0 Pain Relevance 0.88
Given the data suggesting that GABA(B) receptor antagonists display antidepressant properties, the present study was undertaken to assess the effect of antidepressant administration on GABA(B) receptors in the rat hippocampus to determine whether changes in this regional receptor system may play a role in the response to these agents.
Regulation (effect) of GABA in hippocampus associated with antidepressant, gaba, antagonist and hippocampus
16) Confidence 0.38 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451391 Disease Relevance 0.09 Pain Relevance 0.83
Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus.
Regulation (Effect) of GABA in hippocampus associated with gaba, antidepressant and hippocampus
17) Confidence 0.38 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15451391 Disease Relevance 0.10 Pain Relevance 0.90
Ultrastructural relationships between terminals immunoreactive for enkephalin, GABA, or both transmitters in the rat ventral tegmental area.
Regulation (immunoreactive) of GABA in ventral associated with ventral tegmentum, gaba and enkephalin
18) Confidence 0.38 Published 1995 Journal Brain Res. Section Title Doc Link 7538419 Disease Relevance 0.05 Pain Relevance 1.19
Moreover, these findings indicate that nongenomic mechanisms are primarily responsible for the GABA(B) receptor desensitization that occurs during prolonged exposure to receptor agonist.
Regulation (responsible) of GABA associated with gaba and agonist
19) Confidence 0.37 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.15 Pain Relevance 0.86
Role of dynorphin and GABA in the inhibitory regulation of NMDA-induced dopamine release in striosome- and matrix-enriched areas of the rat striatum.
Regulation (Role) of GABA in striatum associated with dopamine, gaba, dynorphin and analgesic
20) Confidence 0.36 Published 1994 Journal J. Neurosci. Section Title Doc Link 7908960 Disease Relevance 0 Pain Relevance 0.79

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