INT291025

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NSF) plasma membrane (NSF) cytoplasm (NSF)
Anatomy Link Frequency
kidney 1
NSF (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 54 100.00 Very High Very High Very High
imagery 12 72.68 Quite High
tolerance 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nephrogenic Fibrosing Dermopathy 56 100.00 Very High Very High Very High
Nephrotoxicity 10 87.00 High High
Poisoning 2 78.24 Quite High
Renal Disease 4 76.80 Quite High
Renal Insufficiency 24 74.16 Quite High
Foreign Bodies 2 43.12 Quite Low
Fibrosis 2 32.96 Quite Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Thrombosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore Omniscan® should not be used in these populations.Neonates and infants:Due to immature kidney function in neonates and infants up to 1 year of age, Omniscan® should only be used in these patients after careful consideration.Undesirable effects:Cases of NSF have been reported with Omniscan®.All other gadolinium — containing contrast agent s should add strong warnings about potential NSF with the following proposed SPC wording :Special warnings and precautions for use:There have been reports of NSF associated with use of some gadolinium-containing contrast agents in patients with severe renal impairment (GFR < 30 ml/min per 1.73 m2).
Positive_regulation (potential) of NSF in kidney associated with fibrosis
1) Confidence 0.34 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 0.63 Pain Relevance 0.29
Meanwhile, after reviewing the issue of nephrogenic systemic fibrosis (NSF) and on the basis of current evidence, it seems that some gadolinium-containing contrast agents may be implicated in its pathogenesis or may even trigger NSF [4–10].
Spec (may) Positive_regulation (trigger) of NSF associated with nephrogenic fibrosing dermopathy and fibrosis
2) Confidence 0.32 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 0.87 Pain Relevance 0.27

General Comments

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