INT291026

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.05
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NSF) plasma membrane (NSF) cytoplasm (NSF)
NSF (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 135 100.00 Very High Very High Very High
cINOD 5 84.28 Quite High
imagery 30 71.84 Quite High
Inflammation 5 67.48 Quite High
tolerance 5 59.48 Quite High
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nephrogenic Fibrosing Dermopathy 140 100.00 Very High Very High Very High
Hypersensitivity 10 99.14 Very High Very High Very High
Nephrotoxicity 25 92.64 High High
Renal Insufficiency 60 87.44 High High
Hyperuricemia 5 86.80 High High
Fibrosis 5 81.36 Quite High
Heart Rate Under Development 5 81.16 Quite High
Increased Venous Pressure Under Development 15 80.04 Quite High
Diabetes Mellitus 5 78.08 Quite High
Renal Disease 10 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of this editorial review is to sensitise healthcare professionals about NSF and the new security guidelines, which also imply differences between the clinically used gadolinium agents and to discuss shortly the following related questions:
Gene_expression (sensitise) of NSF associated with fibrosis
1) Confidence 0.53 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 0.56 Pain Relevance 0.14
Hemodialysis does not necessarily protect from the appearance of NSF, and therefore is not generally recommended after the administration of gadolinium agents [10, 43].
Gene_expression (appearance) of NSF associated with fibrosis
2) Confidence 0.47 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 1.44 Pain Relevance 0.24
Known allergies to any gadolinium contrast agent.Known or diagnosed NSF
Gene_expression (diagnosed) of NSF associated with fibrosis and hypersensitivity
3) Confidence 0.46 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 1.36 Pain Relevance 0.24
Ultimately, this may favour the occurrence of toxic manifestations for compounds with poorer stability¬óbut this has not yet been proven clinically for NSF:
Neg (not) Gene_expression (proven) of NSF associated with fibrosis
4) Confidence 0.46 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 0.27 Pain Relevance 0.10
We must be aware, that this is not a problem of one single drug, but statistically it is just a matter of time to notify NSF incidents for all Gd compounds.
Gene_expression (incidents) of NSF associated with fibrosis
5) Confidence 0.46 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 0.41 Pain Relevance 0.19

General Comments

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