INT291074

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.77 Pain Relevance 0.18

peptidase activity (CFB) extracellular region (CFB) plasma membrane (CFB)

Anatomy Link Frequency adipose tissue 4 fat 2 CFB (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 51 98.56 Inflammation 24 87.16 cytokine 6 46.84 alcohol 6 5.00 aspirin 3 5.00 drug abuse 3 5.00 Angina 3 5.00 Inflammatory marker 3 5.00

Disease Link Frequency Relevance Heat Obesity 189 99.98 Insulin Resistance 69 99.40 Impaired Glucose Tolerance 57 98.56 Disorder Of Lipid Metabolism 27 97.48 INFLAMMATION 27 87.16 Weight Loss 51 83.20 Endotoxemia 9 80.08 Diabetes Mellitus 48 77.40 Metabolic Disorder 15 60.96 Necrosis 6 49.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inversely, CFB gene expression was increased in omental adipose tissue (0.12 ± 0.08 vs. 0.013 ± 0.007 relative units, P < 0.0001).

Positive_regulation (increased) of Gene_expression (expression) of CFB in adipose tissue associated with obesity

1) Confidence 0.45 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.99 Pain Relevance 0

In contrast, CFB gene expression was significantly increased in omental fat but also in association with fasting glucose and triglycerides.

Positive_regulation (increased) of Gene_expression (expression) of CFB in fat

2) Confidence 0.41 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.29 Pain Relevance 0.08

Adipose tissue CFB gene expression tended to be higher in subjects with insulin resistance (Table 3B), and omental CFB gene expression was significantly associated with fasting glucose and triglycerides (positively) and negatively with HDL cholesterol (Table 3A).

Positive_regulation (higher) of Gene_expression (expression) of CFB in Adipose tissue associated with obesity, insulin resistance and disorder of lipid metabolism

3) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.49 Pain Relevance 0.11

General Comments

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