INT291084

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn5) plasma membrane (Cldn5)
Anatomy Link Frequency
brain 1
Cldn5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 54 97.08 Very High Very High Very High
ischemia 14 64.96 Quite High
anesthesia 4 28.08 Quite Low
isoflurane 2 17.92 Low Low
imagery 6 15.12 Low Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 10 94.44 High High
Diabetes Mellitus 180 92.76 High High
Cv Unclassified Under Development 6 64.96 Quite High
Brain Hemorrhage 40 53.12 Quite High
Peripheral Arterial Disease 8 45.84 Quite Low
Coronary Artery Disease 6 44.56 Quite Low
Pathologic Neovascularization 2 38.64 Quite Low
Stroke 36 37.36 Quite Low
Pressure And Volume Under Development 18 27.60 Quite Low
Injury 26 26.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homogenates were immunoblotted with occludin and claudin-5 (Zymed Laboratories, Carlsbad, CA), collagen IV (Abcam, Cambridge, MA), MMP-2, and MMP-9 (Calbiochem, Gibbstown, NJ) antibodies, respectively.
Localization (immunoblotted) of claudin-5 associated with metalloproteinase
1) Confidence 0.31 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.05 Pain Relevance 0.16
Since tight junction proteins such as occludin and claudin-5 have essential roles in regulating BBB stability (36), we evaluated abundance of occludin, claudin-5, and collagen IV in the isolated micro- and macrovascular vessels from the brain.
Localization (abundance) of claudin-5 in brain
2) Confidence 0.31 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.79 Pain Relevance 0.13

General Comments

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