INT2911

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 36
Total Number 41
Disease Relevance 11.09
Pain Relevance 22.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
neurons 4
globus pallidus 3
striatum 2
retinas 1
muscle 1
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 582 100.00 Very High Very High Very High
Glutamate 204 100.00 Very High Very High Very High
gABA 48 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
Morphine 509 99.98 Very High Very High Very High
antidepressant 7 99.98 Very High Very High Very High
narcan 403 99.84 Very High Very High Very High
qutenza 6 99.70 Very High Very High Very High
cocaine 10 99.68 Very High Very High Very High
Hyperalgesia 6 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 212 99.98 Very High Very High Very High
Generalized Anxiety Disorder 8 99.92 Very High Very High Very High
Catalepsy 24 99.90 Very High Very High Very High
Vibrio Infection 31 99.86 Very High Very High Very High
Glioma 8 99.44 Very High Very High Very High
Hyperalgesia 13 99.36 Very High Very High Very High
Aids-related Complex 4 99.00 Very High Very High Very High
Neurological Disease 8 98.32 Very High Very High Very High
Dystonia 16 97.20 Very High Very High Very High
Liver Disease 2 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in glutamine synthetase activity in wounded muscle was prevented by adrenalectomy and restored by replacement doses of corticosterone in wounded adrenalectomized animals.
Positive_regulation (increase) of glutamine synthetase in muscle
1) Confidence 0.70 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2880509 Disease Relevance 0.07 Pain Relevance 0.16
Maximal glutamine synthetase activity was increased by wounding.
Positive_regulation (increased) of glutamine synthetase
2) Confidence 0.61 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2880509 Disease Relevance 0.06 Pain Relevance 0.17
Compared to vehicle, capsaicin significantly increased GFAP and GS immunoreactivity in the ARC-ME.
Positive_regulation (increased) of GS associated with qutenza and aids-related complex
3) Confidence 0.49 Published 2004 Journal Neuroreport Section Abstract Doc Link 15076747 Disease Relevance 0.36 Pain Relevance 0.46
Glutamate decarboxylase (67000 mol. wt) messenger RNA levels were increased in the Purkinje cells and decreased in the deep cerebellar nuclei of dystonic rats compared to control littermates, suggesting opposite changes in GABAergic transmission in Purkinje cells and in their target neurons in the deep cerebellar nuclei.
Positive_regulation (increased) of Glutamate decarboxylase in neurons associated with glutamate, gabaergic and dystonia
4) Confidence 0.46 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466432 Disease Relevance 0.78 Pain Relevance 0.45
Although without effect alone, guanosine-5'-[gamma-thio]triphosphate (GTP gamma S) and cholera toxin--which activate Gs--both increased, while guanosine-5'-[beta-thio] diphosphate (GDP beta S)--which prevents the activation of Gs--decreased the hyperalgesia induced by PGE2.
Positive_regulation (activation) of Gs in PGE2 associated with hyperalgesia and vibrio infection
5) Confidence 0.45 Published 1989 Journal Brain Res. Section Abstract Doc Link 2502301 Disease Relevance 0.36 Pain Relevance 0.44
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes

Purpose

Positive_regulation (preserving) of glutamine synthetase in neurons associated with diabetes mellitus
6) Confidence 0.40 Published 2010 Journal Molecular Vision Section Title Doc Link PMC2925907 Disease Relevance 0.76 Pain Relevance 0.09
Acute administration of morphine induced significant increases of gamma-amino-butyric acid (GABA) content and L-glutamate decarboxylase (GAD) activity at the dorsal parts of the dorsal horn and surroundings of the central canal in the rat spinal cord, in which GABA inhibitory interneurons may play significant roles.
Positive_regulation (increases) of L-glutamate decarboxylase in dorsal horn associated with glutamate, gaba, generalized anxiety disorder, dorsal horn, spinal cord and morphine
7) Confidence 0.39 Published 1978 Journal Brain Res. Section Abstract Doc Link 566149 Disease Relevance 0.18 Pain Relevance 0.88
Indeed, diabetes-induced GS tyrosine nitration was positively correlated with a significant inhibition (40%) of GS activity (Figure 4), and treatment with CBD restored this activity in the diabetic animals.
Positive_regulation (induced) of GS associated with diabetes mellitus
8) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 1.09 Pain Relevance 0.04
Brain glutamine synthetase activity is not increased in PCS rats and in some areas of the brain there may even be a decrease in activity.
Neg (not) Positive_regulation (increased) of glutamine synthetase in Brain
9) Confidence 0.37 Published 1990 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2103690 Disease Relevance 0.29 Pain Relevance 0.08
Our results showed a 2.3 fold increase in GS tyrosine nitration that was associated with a significant reduction (40%) in GS activity in diabetic retinas compared with controls.
Positive_regulation (increase) of GS in retinas associated with diabetes mellitus
10) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 0.75 Pain Relevance 0.19
In contrast, levels of glutamate decarboxylase (67000 mol. wt) messenger RNA in the pallidum, and of enkephalin messenger RNA in the striatum, were unaffected in dystonic rats.
Positive_regulation (levels) of glutamate decarboxylase in striatum associated with glutamate, dystonia and enkephalin
11) Confidence 0.33 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466432 Disease Relevance 0.71 Pain Relevance 0.47
In view of these observations the pharmacological agents who can increase GS may prove beneficial in the treatment of neurological disorders involving excitotoxicity as a result of anoxia.
Positive_regulation (increase) of GS associated with neurological disease and hypoxia
12) Confidence 0.33 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.46 Pain Relevance 0.23
Double and triple labelling results showed that all the alpha1-subunit-immunoreactive neurons were positive for glutamate decarboxylase and immunoreactive for the beta2,3 and gamma2 subunits of the GABA(A) receptor.
Positive_regulation (positive) of glutamate decarboxylase in neurons associated with gaba and glutamate
13) Confidence 0.30 Published 1997 Journal Neuroscience Section Abstract Doc Link 9276493 Disease Relevance 0 Pain Relevance 0.18
Results from previous studies suggested that chronic treatment of rats or C6 glioma cells with antidepressants augments the coupling between Gs and adenylyl cyclase.
Positive_regulation (augments) of Gs associated with antidepressant and glioma
14) Confidence 0.30 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461902 Disease Relevance 0.39 Pain Relevance 0.31
CONCLUSION: Intrathecal dexamethasone attenuates long-term morphine infusion-induced glutamate dehydrogenase and glutamate synthetase downregulation and antinociceptive tolerance.


Positive_regulation (induced) of glutamate synthetase
15) Confidence 0.29 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17312234 Disease Relevance 0 Pain Relevance 0
Different regimens of haloperidol (1 mg/kg s.c., three, seven or 14 days; 2 mg/kg, s.c., 10 days) induced catalepsy in a majority of rats and increased glutamate decarboxylase messenger RNA levels in the globus pallidus (external pallidum) in those rats exhibiting catalepsy.
Positive_regulation (increased) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
16) Confidence 0.29 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.36 Pain Relevance 0.29
Levels of glutamate decarboxylase messenger RNA were also increased in the entopeduncular nucleus (internal pallidum), but only after 14 days of treatment with haloperidol.
Positive_regulation (increased) of glutamate decarboxylase in internal associated with glutamate
17) Confidence 0.29 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.42 Pain Relevance 0.35
When co-administered with haloperidol (seven days, 1 mg/kg s.c.), the muscarinic antagonist scopolamine (1 mg/kg, s.c.) completely blocked both haloperidol-induced catalepsy and increases in glutamate decarboxylase messenger RNA levels in the globus pallidus.
Positive_regulation (increases) of glutamate decarboxylase in globus pallidus associated with glutamate, catalepsy and antagonist
18) Confidence 0.29 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.47 Pain Relevance 0.50
These results reveal a good correlation between increases in glutamate decarboxylase messenger RNA levels in the globus pallidus and catalepsy after these drug treatments and suggest that anticholinergic blockade of the behavioral and molecular effects of neuroleptics may involve non-striatal mechanisms.
Positive_regulation (increases) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
19) Confidence 0.29 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.39 Pain Relevance 0.47
Morphine induced alterations of gamma-aminobutyric acid and taurine contents and L-glutamate decarboxylase activity in rat spinal cord and thalamus: possible correlates with analgesic action of morphine.
Spec (possible) Positive_regulation (induced) of L-glutamate decarboxylase in spinal cord associated with glutamate, analgesic, thalamus, spinal cord and morphine
20) Confidence 0.28 Published 1978 Journal Brain Res. Section Title Doc Link 566149 Disease Relevance 0.30 Pain Relevance 1.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox