INT291105

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FFAR1, PDP1) mitochondrion (PDP1) plasma membrane (FFAR1)
signal transducer activity (FFAR1)
Anatomy Link Frequency
plasma 1
fat 1
muscle 1
skeletal muscle 1
FFAR1 (Homo sapiens)
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 16 99.08 Very High Very High Very High
Diabetes Mellitus 4 97.96 Very High Very High Very High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, although there was no effect of elevated FFA on PDHa activity at rest in the present study, maybe due to the overnight high-fat diet in both trials, elevated FFA levels have been shown to induce insulin resistance (31,32), and individuals with enhanced circulating FFA levels like type 2 diabetic subjects may experience FFA-mediated insulin resistance at rest (33), potentially in part because of FFA-induced downregulation of PDH (1).
FFA-induced Negative_regulation (downregulation) of PDH in fat associated with diabetes mellitus and insulin resistance
1) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.29 Pain Relevance 0
The activation of PDH by exercise independent of changes in muscle glycogen or plasma FFA suggests that exercise overrules FFA-mediated inhibition of PDH (i.e., carbohydrate oxidation), and this may thus be one mechanism behind the health-promoting effects of exercise.



FFA-mediated Negative_regulation (inhibition) of PDH in muscle
2) Confidence 0.05 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Also based on findings in rat skeletal muscle, plasma FFA is also believed to reduce PDH activity through a peroxisome proliferator–activated receptor (PPAR)-?
FFA Negative_regulation (reduce) of PDH in plasma
3) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Also based on findings in rat skeletal muscle, plasma FFA is also believed to reduce PDH activity through a peroxisome proliferator–activated receptor (PPAR)-?
FFA Negative_regulation (reduce) of PDH in skeletal muscle
4) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

General Comments

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