INT291144

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
skeletal muscle 6
muscle 2
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 16 89.96 High High
Repression 4 61.68 Quite High
Diabetes Mellitus 4 59.44 Quite High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the smaller increase in PDHa activity and the smaller decline in PDH dephosphorylation in response to exercise when muscle glycogen was reduced or plasma FFA concentration was elevated initially suggest that each of these factors may modify exercise-induced PDH regulation.
Positive_regulation (induced) of Regulation (regulation) of PDH in muscle
1) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.24 Pain Relevance 0
Regulation of PDH activity in human skeletal muscle is believed mainly to be mediated through changes in the phosphorylation state of site one (Ser293) and two (Ser300) on the PDH-E1?
Positive_regulation (mediated) of Regulation (Regulation) of PDH in skeletal muscle
2) Confidence 0.43 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.16 Pain Relevance 0
Therefore, the aim of the present study was to test the hypothesis that both low muscle glycogen and elevated FFA modify exercise-induced PDH regulation in human skeletal muscle independent of each other, potentially through regulation of PDK4 expression.
Positive_regulation (induced) of Regulation (regulation) of PDH in skeletal muscle
3) Confidence 0.43 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Muscle glycogen and plasma FFA attenuate exercise-induced PDH regulation in human skeletal muscle in a nonadditive manner.
Positive_regulation (induced) of Regulation (regulation) of PDH in skeletal muscle
4) Confidence 0.43 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

General Comments

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