INT291148

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 1.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
skeletal muscle 8
muscle 3
leg 2
plasma 1
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 16 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
Immobilon 16 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 64 89.96 High High
Repression 16 89.32 High High
Diabetes Mellitus 16 59.12 Quite High
Sprains And Strains 16 5.00 Very Low Very Low Very Low
Body Weight 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, regulation of PDH seems to be under both local and systemic control (17).
Regulation (regulation) of PDH
1) Confidence 0.57 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.06 Pain Relevance 0
Thus, the clear differences in exercise-induced muscle glucose-6-phosphate and muscle glucose responses in the normal and the low muscle glycogen muscles in the high FFA trial were not associated with differences in PDH regulation, and despite similar muscle glucose-6-phosphate and muscle glucose levels in the normal glycogen leg in the two trials, PDHa activity was higher in the low FFA trial than in the high FFA trial.
Regulation (regulation) of PDH in leg
2) Confidence 0.57 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Glycolytic flux has been suggested to be one factor regulating PDH and hence the flux through the pyruvate dehydrogenase complex (29,35,38).
Regulation (regulating) of PDH
3) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Such interpretation is supported by the observation that lower glycogen utilization in the low glycogen muscle than in the normal glycogen muscle occurred without influence on PDH regulation in the high FFA trial.
Regulation (regulation) of PDH in muscle
4) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Thus, the impact on PDH regulation associated with low muscle glycogen and elevated plasma FFA was not additive, which may suggest that a similar underlying mechanism could be involved in exerting this effect on PDHa activity.
Regulation (regulation) of PDH in plasma
5) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.09 Pain Relevance 0
Regulation of PDH activity in human skeletal muscle is believed mainly to be mediated through changes in the phosphorylation state of site one (Ser293) and two (Ser300) on the PDH-E1?
Regulation (changes) of PDH in skeletal muscle
6) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.16 Pain Relevance 0
The possibility that changes in PDK4 protein expression may have mediated the observed association between muscle glycogen and PDH regulation as well as between plasma FFA and PDH regulation is supported by the observation that the highest PDH activation and largest dephosphorylation occurred in the leg and trial with lowest PDK4 protein expression.
Regulation (regulation) of PDH in leg
7) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.08 Pain Relevance 0
In addition, the smaller increase in PDHa activity and the smaller decline in PDH dephosphorylation in response to exercise when muscle glycogen was reduced or plasma FFA concentration was elevated initially suggest that each of these factors may modify exercise-induced PDH regulation.
Regulation (regulation) of PDH in muscle
8) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.24 Pain Relevance 0
Regulation of PDH activity in human skeletal muscle is believed mainly to be mediated through changes in the phosphorylation state of site one (Ser293) and two (Ser300) on the PDH-E1?
Regulation (Regulation) of PDH in skeletal muscle
9) Confidence 0.25 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.16 Pain Relevance 0
The impact of exercise on PDH regulation in skeletal muscle unrelated to the metabolic status of the cell and body may reflect that exercise can overcome potential inhibition of carbohydrate utilization present in resting skeletal muscle when circulating FFA levels are increased (2).
Regulation (regulation) of PDH in skeletal muscle
10) Confidence 0.25 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.17 Pain Relevance 0
Muscle glycogen and plasma FFA attenuate exercise-induced PDH regulation in human skeletal muscle in a nonadditive manner.
Regulation (regulation) of PDH in skeletal muscle
11) Confidence 0.25 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Therefore, the aim of the present study was to test the hypothesis that both low muscle glycogen and elevated FFA modify exercise-induced PDH regulation in human skeletal muscle independent of each other, potentially through regulation of PDK4 expression.
Regulation (regulation) of PDH in skeletal muscle
12) Confidence 0.25 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
The present finding that exercise increased the PDHa activity at least threefold independent of differences in muscle glycogen concentration, and despite enhanced plasma FFA levels, demonstrates that mechanisms other than muscle glycogen and plasma FFA dominate exercise-induced PDH regulation in human skeletal muscle.
Regulation (regulation) of PDH in skeletal muscle
13) Confidence 0.25 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
In conclusion, muscle glycogen and plasma FFAs modify exercise-induced PDH regulation in human skeletal muscle in a nonadditive manner, which might be through glycogen and FFA-mediated regulation of PDK4 expression.
Regulation (regulation) of PDH in skeletal muscle
14) Confidence 0.25 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Skeletal muscle PDH activity is affected by fasting, high-fat diet, and exercise (4,10–13).
Regulation (affected) of PDH in Skeletal muscle
15) Confidence 0.22 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.13 Pain Relevance 0
To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression.


Regulation (regulation) of PDH in muscle
16) Confidence 0.22 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

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