INT291152

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 0.97
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
muscle 3
skeletal muscle 3
legs 2
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 11 53.84 Quite High
imagery 11 38.80 Quite Low
lidocaine 11 20.44 Low Low
anesthesia 11 20.00 Low Low
Disease Link Frequency Relevance Heat
Repression 11 99.56 Very High Very High Very High
Insulin Resistance 44 85.60 High High
Diabetes Mellitus 11 79.44 Quite High
Sprains And Strains 11 43.92 Quite Low
Body Weight 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the observation that the highest exercise-induced PDHa activity and largest PDH dephosphorylation were present when the muscle glycogen level was only moderately reduced and when FFA remained close to baseline levels (193 ?
Phosphorylation (dephosphorylation) of PDH in muscle
1) Confidence 0.76 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.24 Pain Relevance 0
and PDK4 protein expression and phosphorylation of PDH-E1?
Phosphorylation (phosphorylation) of PDH
2) Confidence 0.76 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0.03
Regulation of PDH activity in human skeletal muscle is believed mainly to be mediated through changes in the phosphorylation state of site one (Ser293) and two (Ser300) on the PDH-E1?
Phosphorylation (phosphorylation) of PDH in skeletal muscle
3) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.15 Pain Relevance 0
A relation between muscle glycogen levels and PDHa activity and PDH phosphorylation is in line with our previous finding that further lowering of muscle glycogen during high-intensity exercise was associated with reduced PDHa activity (17).
Phosphorylation (phosphorylation) of PDH in muscle
4) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.13 Pain Relevance 0
Of notice is also that the same degree of repression of PDHa activity and PDH dephosphorylation changes was evident when muscle glycogen was lowered to 268 mmol/kg dry wt or plasma FFA was elevated to 714 ?
Phosphorylation (dephosphorylation) of PDH in muscle associated with repression
5) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.10 Pain Relevance 0
Such an effect of FFA is in accordance with previous studies, indicating that FFA downregulates PDHa activity or increases PDH phosphorylation in rat (1) and human (12) skeletal muscle at rest.
Phosphorylation (phosphorylation) of PDH in skeletal muscle
6) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.23 Pain Relevance 0
Moreover, the association between PDK4 protein content and both PDH phosphorylation and PDHa activity also supports that such PDK4 expression changes may have a functional role in regulating substrate utilization in human skeletal muscle to match availability.
Phosphorylation (phosphorylation) of PDH in skeletal muscle
7) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
The phosphorylation data are presented as relative phosphorylation (normalized to the PDH-E1?
Phosphorylation (phosphorylation) of PDH
8) Confidence 0.58 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Increases in mitochondrial calcium levels are likely important, since mitochondrial calcium concentration increases during exercise (4,21) and calcium has been shown to activate PDP1 leading to dephosphorylation and activation of PDH (30).
Phosphorylation (dephosphorylation) of PDH
9) Confidence 0.58 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.11 Pain Relevance 0
0.05) a dephosphorylation of PDH-P1 (to 20–45% of prelevel) and PDH-P2 (34–65% of prelevel) in both trials and legs (Fig. 3 and Fig. 4C and D).
Phosphorylation (dephosphorylation) of PDH-P1 in legs
10) Confidence 0.58 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
0.05) a dephosphorylation of PDH-P1 (to 20–45% of prelevel) and PDH-P2 (34–65% of prelevel) in both trials and legs (Fig. 3 and Fig. 4C and D).
Phosphorylation (dephosphorylation) of PDH-P2 in legs
11) Confidence 0.58 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

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