INT291182

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.53
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) cellular_component (Tek)
Tek (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 60 91.36 High High
ischemia 16 61.44 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 372 99.48 Very High Very High Very High
Myocardial Infarction 276 97.24 Very High Very High Very High
Ventricular Remodeling 40 94.76 High High
Fibrosis 64 91.36 High High
Coronary Artery Disease 20 61.44 Quite High
Cv Unclassified Under Development 12 58.00 Quite High
Hyperglycemia 4 56.20 Quite High
Targeted Disruption 12 20.00 Low Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Heart Rate Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in the expression of the receptors Flk-1 and Tie-2 that we observed upon gene therapy can be correlated to the increased expression of their ligands: VEGF and Ang-1, respectively.
Positive_regulation (increase) of Gene_expression (expression) of Tie-2
1) Confidence 0.24 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.06 Pain Relevance 0.03
Similarly, we observed a significant increase in the expression of Ang-1 (4.0-fold) and Tie-2 (2.1-fold) in the diabetic animals that received the therapy (DVAMI), 4 days after the treatment, compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 4C and D).


Positive_regulation (increase) of Gene_expression (expression) of Tie-2 associated with diabetes mellitus and myocardial infarction
2) Confidence 0.17 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.01 Pain Relevance 0
We also observed increased phosphorylated mitogen-activated protein kinase┬ľactivated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor (VEGF), Flk-1, angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals.
Positive_regulation (increased) of Gene_expression (expression) of Tie-2 associated with diabetes mellitus
3) Confidence 0.16 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 1.20 Pain Relevance 0.07
We also observed increased phosphorylated mitogen-activated protein kinase┬ľactivated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor (VEGF), Flk-1, angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals.
Positive_regulation (increased) of Gene_expression (expression) of Tie-2 associated with diabetes mellitus
4) Confidence 0.16 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 1.26 Pain Relevance 0.07

General Comments

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