INT291184

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.81
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
inner nuclear layer 3
plasma 2
retina 2
ganglion cell layer 1
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 90 97.88 Very High Very High Very High
corticosteroid 30 94.16 High High
cytokine 14 18.80 Low Low
fibrosis 15 18.68 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 296 100.00 Very High Very High Very High
Diabetes Mellitus 313 99.84 Very High Very High Very High
Ganglion Cysts 8 99.12 Very High Very High Very High
Glioma 58 99.00 Very High Very High Very High
Papilledema 4 95.84 Very High Very High Very High
Myocardial Infarction 69 94.00 High High
Malignant Neoplastic Disease 2 88.20 High High
Diabetic Macular Edema 84 85.12 High High
Injury 8 79.44 Quite High
Ventricular Remodeling 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Neg (not) Regulation (alter) of Gene_expression (levels) of FLK-1 in retina
1) Confidence 0.54 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.67 Pain Relevance 0.05
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Regulation (found) of Gene_expression (expression) of FLK-1 in inner nuclear layer associated with ganglion cysts
2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.51 Pain Relevance 0
Relative changes in Vegf-a, Flk-1, and Flt-1 mRNA expression.
Regulation (changes) of Gene_expression (expression) of Flk-1
3) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.26 Pain Relevance 0
This study was to determine the changes in tumor size, vascular permeability, fractional plasma volume and expression of VEGFR2 in PTK787 treated U-251 glioma rat model by in vivo magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT).
Spec (determine) Regulation (changes) of Gene_expression (expression) of VEGFR2 in plasma associated with cancer, imagery and glioma
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806917 Disease Relevance 0.85 Pain Relevance 0.12
However, changes in the tumor size, tumor vascular permeability, vascular density, expression of VEGFR2 and other angiogenic factors in response to PTK787 are not well documented.
Regulation (changes) of Gene_expression (expression) of VEGFR2 associated with cancer
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806917 Disease Relevance 0.81 Pain Relevance 0.08
Effect of gene therapy on the expression of VEGF and Flk-1.
Regulation (Effect) of Gene_expression (expression) of Flk-1
6) Confidence 0.14 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.22 Pain Relevance 0
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Regulation (found) of in ganglion cell layer Gene_expression (expression) of FLK-1 in inner nuclear layer associated with ganglion cysts
7) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.51 Pain Relevance 0

General Comments

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