INT291186

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.27
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) cellular_component (Tek)
Tek (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 30 55.08 Quite High
ischemia 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 138 99.30 Very High Very High Very High
Fibrosis 32 98.32 Very High Very High Very High
Ventricular Remodeling 20 96.92 Very High Very High Very High
Diabetes Mellitus 186 91.16 High High
Stress 4 89.36 High High
Heart Rate Under Development 4 67.40 Quite High
Hyperkinesis 2 36.20 Quite Low
Heart Disease 2 32.72 Quite Low
Coronary Artery Disease 10 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The therapy significantly reduced the ventricular remodeling as evidenced by the significant reduction in the collagenous fibrotic tissue and improvement in the myocardial functions in conjunction with significant increase in the levels of VEGF and its receptor Flk-1, Ang-1 and its receptor Tie-2, p-MK2, and antiapoptotic survivin.
Positive_regulation (increase) of Tie-2 associated with fibrosis and ventricular remodeling
1) Confidence 0.24 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.16 Pain Relevance 0.03
Upon treatment with a combination of adenoviral vectors encoding VEGF and Ang-1 in the nondiabetic MI (CVAMI) animals, we documented an increase in the levels of Ang-1 (1.3-fold) and Tie-2 (1.3-fold) 4 days after the gene transfer compared with the Ad.LacZ-treated nondiabetic MI (CLZMI) group (Fig. 4C and D).
Positive_regulation (increase) of Tie-2 associated with myocardial infarction
2) Confidence 0.16 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.12 Pain Relevance 0

General Comments

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