INT2912

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1978
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 29
Total Number 35
Disease Relevance 6.48
Pain Relevance 27.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
brain 12
neuronal 4
substantia nigra 4
neurons 4
entopeduncular nucleus 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 382 100.00 Very High Very High Very High
carbamazepine 22 100.00 Very High Very High Very High
Potency 10 100.00 Very High Very High Very High
Gabapentin 111 99.98 Very High Very High Very High
agonist 66 99.98 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
Lamotrigine 43 99.92 Very High Very High Very High
nMDA receptor 7 99.80 Very High Very High Very High
withdrawal 8 99.76 Very High Very High Very High
Thalamus 21 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 99.48 Very High Very High Very High
Pain 10 99.46 Very High Very High Very High
Convulsion 157 98.68 Very High Very High Very High
Stress 13 97.96 Very High Very High Very High
Urological Neuroanatomy 4 97.28 Very High Very High Very High
Neuropathic Pain 8 96.64 Very High Very High Very High
Epilepsy 128 94.92 High High
Manic Depressive Disorder 72 87.04 High High
Disease 12 85.04 High High
Inflammatory Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, tiagabine could inhibit or disinhibit globus pallidus neurons by increasing the activation of the GABA(A) receptors and presynaptic GABA(B) receptors, respectively.
Positive_regulation (increasing) of Positive_regulation (activation) of GABA in neurons associated with gaba
1) Confidence 0.66 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12879169 Disease Relevance 0 Pain Relevance 0.59
Thus, tiagabine could inhibit or disinhibit globus pallidus neurons by increasing the activation of the GABA(A) receptors and presynaptic GABA(B) receptors, respectively.
Positive_regulation (increasing) of Positive_regulation (activation) of GABA in neurons associated with gaba
2) Confidence 0.47 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12879169 Disease Relevance 0 Pain Relevance 0.59
The results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35S]GTPgammaS binding and GABA(B) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in GABAergic transmission.
Spec (partial) Positive_regulation (increases) of Positive_regulation (baclofen-stimulated) of GABA in spinal cord associated with pain, gaba, gabaergic, neuropathic pain, sciatic nerve, withdrawal and spinal cord
3) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.73 Pain Relevance 1.37
In the thalamus, morphine also induced significant increases of GABA content and GAD activity in the vicinity of the ventrolateral part of the ventral nucleus (VM), entopeduncular nucleus (EP), nucleus reuniens thalami (RE), nucleus parafascicularis thalami (PF) and interpeduncular nucleus (IP), respectively.
Positive_regulation (induced) of Positive_regulation (increases) of GABA in entopeduncular nucleus associated with gaba, generalized anxiety disorder, thalamus and morphine
4) Confidence 0.46 Published 1978 Journal Brain Res. Section Abstract Doc Link 566149 Disease Relevance 0.32 Pain Relevance 1.20
In addition, we observed that only acute withdrawal moderately increased stimulated GABA release.
Positive_regulation (increased) of Positive_regulation (stimulated) of GABA associated with gaba and withdrawal
5) Confidence 0.44 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16540107 Disease Relevance 0.14 Pain Relevance 1.18
In the present study, the gamma-aminobutyric acid (GABA) accumulation induced by aminooxyacetic acid (AOAA) was used as a method to study the effects of gabapentin on regional turnover of GABA in the rat brain.
Positive_regulation (induced) of Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
6) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1945036 Disease Relevance 0.28 Pain Relevance 0.78
Gabapentin significantly increased the AOAA-induced GABA accumulation in most of the 12 brain regions examined, but the time course of the increases in GABA accumulation differed from region to region.
Positive_regulation (increased) of Spec (examined) Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
7) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1945036 Disease Relevance 0.24 Pain Relevance 1.12
Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.
Positive_regulation (increases) of Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
8) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1945036 Disease Relevance 0.28 Pain Relevance 1.03
Regions in which the time course of the increase in GABA accumulation was similar to the anticonvulsant time course of gabapentin included substantia nigra, amygdala and thalamus.
Positive_regulation (increase) of Positive_regulation (accumulation) of GABA in substantia nigra associated with gaba, substantia nigra, thalamus, anticonvulsant, amygdala and gabapentin
9) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1945036 Disease Relevance 0.21 Pain Relevance 1.16
Gabapentin significantly increased the AOAA-induced GABA accumulation in most of the 12 brain regions examined, but the time course of the increases in GABA accumulation differed from region to region.
Positive_regulation (increases) of Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
10) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1945036 Disease Relevance 0.23 Pain Relevance 1.14
Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.
Positive_regulation (induced) of Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
11) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1945036 Disease Relevance 0.28 Pain Relevance 1.03
Gabapentin significantly increased the AOAA-induced GABA accumulation in most of the 12 brain regions examined, but the time course of the increases in GABA accumulation differed from region to region.
Spec (examined) Positive_regulation (induced) of Spec (examined) Positive_regulation (accumulation) of GABA in brain associated with gaba and gabapentin
12) Confidence 0.41 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1945036 Disease Relevance 0.24 Pain Relevance 1.11
This stressor, like novelty, caused an increase in hippocampal GABA, suggesting a stimulatory effect of psychological stress.
Positive_regulation (caused) of Positive_regulation (increase) of GABA associated with stress and gaba
13) Confidence 0.40 Published 2007 Journal Neuroscience Section Abstract Doc Link 17693036 Disease Relevance 0.22 Pain Relevance 0.59
Co-infusion with tetrodotoxin (1 microM) did not antagonize the increase of GABA induced by L-NMMA.
Neg (not) Positive_regulation (induced) of Positive_regulation (increase) of GABA associated with tetrodotoxin and gaba
14) Confidence 0.40 Published 1995 Journal Neuroreport Section Abstract Doc Link 7488740 Disease Relevance 0 Pain Relevance 0.45
Co-infusion with tetrodotoxin (1 microM) did not antagonize the increase of GABA induced by L-NMMA.
Positive_regulation (increase) of Neg (not) Positive_regulation (induced) of GABA associated with tetrodotoxin and gaba
15) Confidence 0.40 Published 1995 Journal Neuroreport Section Abstract Doc Link 7488740 Disease Relevance 0 Pain Relevance 0.45
Novelty caused a fast increase in GABA (120% of baseline), whereas forced swimming resulted in a profound decrease (70% of baseline).
Positive_regulation (caused) of Positive_regulation (increase) of GABA associated with gaba
16) Confidence 0.40 Published 2007 Journal Neuroscience Section Abstract Doc Link 17693036 Disease Relevance 0.27 Pain Relevance 0.64
Acute administration of morphine induced significant increases of gamma-amino-butyric acid (GABA) content and L-glutamate decarboxylase (GAD) activity at the dorsal parts of the dorsal horn and surroundings of the central canal in the rat spinal cord, in which GABA inhibitory interneurons may play significant roles.
Positive_regulation (induced) of in dorsal Positive_regulation (increases) of GABA in dorsal horn associated with glutamate, gaba, generalized anxiety disorder, dorsal horn, spinal cord and morphine
17) Confidence 0.40 Published 1978 Journal Brain Res. Section Abstract Doc Link 566149 Disease Relevance 0.17 Pain Relevance 0.87
(b) The enhancement (by antibodies to GM1 ganglioside) of GABA release induced by high K+ levels occurred in the presence of tetrodotoxin (0.01 microM).
Positive_regulation (enhancement) of Positive_regulation (induced) of GABA associated with tetrodotoxin and gaba
18) Confidence 0.40 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2434615 Disease Relevance 0 Pain Relevance 0.31
Also, perfusion of the dialysis probes with potassium (100 mmol/L) induced an increase of the GABA level.
Positive_regulation (induced) of Positive_regulation (increase) of GABA associated with gaba
19) Confidence 0.39 Published 1994 Journal Neurosurgery Section Abstract Doc Link 8190224 Disease Relevance 0.05 Pain Relevance 0.91
The injection of formaldehyde induced a biphasic behavioural response and an increase of the GABA levels at 15-45 min.
Positive_regulation (induced) of Positive_regulation (increase) of GABA associated with gaba
20) Confidence 0.37 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288579 Disease Relevance 0.20 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox