INT29120

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Context Info
Confidence 0.04
First Reported 1987
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 12 100.00 Very High Very High Very High
Substantia nigra 5 99.04 Very High Very High Very High
opiate 4 98.88 Very High Very High Very High
gABA 6 97.76 Very High Very High Very High
dopamine receptor 1 93.84 High High
agonist 2 90.00 High High
Dopamine 4 87.76 High High
Glutamate 2 85.76 High High
Cholecystokinin 1 80.28 Quite High
substance P 2 79.04 Quite High
Disease Link Frequency Relevance Heat
Disease 4 99.78 Very High Very High Very High
Reprotox - General 1 5 75.88 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 54.36 Quite High
Cancer 9 50.00 Quite Low
Breast Cancer 2 28.96 Quite Low
Death 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Rupture 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Competition of receptorphin for [125I]Tyr11-somatostatin14 binding revealed that the peptide could decrease somatostatin binding with an IC50 of 18.9 ± 1.02 × 10-9 M, comparable with the antiproliferative effect of the peptide on LNCaP cells, indicating a significant interaction of receptorphin with somatostatin receptors.


Negative_regulation (decrease) of somatostatin Binding (binding) of associated with somatostatin
1) Confidence 0.04 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60649 Disease Relevance 0.08 Pain Relevance 0.54
In the SN of patients with Parkinson's disease, there is reduced binding of somatostatin, neurotensin, mu and kappa opiates, benzodiazepine and GABA and glycine.
Negative_regulation (reduced) of somatostatin Binding (binding) of associated with gaba, substantia nigra, somatostatin, opiate and disease
2) Confidence 0.01 Published 1987 Journal Can J Neurol Sci Section Abstract Doc Link 2824009 Disease Relevance 0.39 Pain Relevance 1.42

General Comments

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