INT291212

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.86
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
macrophages 4
3T3-L1 2
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 117 95.72 Very High Very High Very High
Inflammation 78 95.32 Very High Very High Very High
Inflammatory mediators 6 84.08 Quite High
Inflammatory stimuli 15 67.52 Quite High
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 318 99.56 Very High Very High Very High
INFLAMMATION 99 95.32 Very High Very High Very High
Diabetes Mellitus 24 82.08 Quite High
Cancer 15 50.00 Quite Low
Necrosis 9 50.00 Quite Low
Insulin Resistance 30 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data strongly support an activation of Tpl2, because Tpl2 degradation by the proteasome is tightly coupled to its activation in macrophages (29,30).
Positive_regulation (coupled) of Protein_catabolism (degradation) of Tpl2 in macrophages
1) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.71 Pain Relevance 0.16
These data strongly support an activation of Tpl2, because Tpl2 degradation by the proteasome is tightly coupled to its activation in macrophages (29,30).
Positive_regulation (by) of Protein_catabolism (degradation) of Tpl2 in macrophages
2) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.70 Pain Relevance 0.16
(45 min) induced Tpl2 degradation in 3T3-L1 adipocytes, prolonged treatment with IL-1?
Positive_regulation (induced) of Protein_catabolism (degradation) of Tpl2 in 3T3-L1 associated with obesity
3) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.45 Pain Relevance 0.10

General Comments

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