INT291213

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
macrophages 2
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 97.40 Very High Very High Very High
Inflammation 52 97.12 Very High Very High Very High
Inflammatory mediators 4 23.60 Low Low
Inflammatory stimuli 10 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 97.12 Very High Very High Very High
Obesity 212 95.28 Very High Very High Very High
Diabetes Mellitus 16 59.24 Quite High
Cancer 10 50.00 Quite Low
Necrosis 6 50.00 Quite Low
Targeted Disruption 2 19.60 Low Low
Insulin Resistance 20 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
macrophages, whereas Tpl2 protein expression is markedly reduced due to its degradation (29).
Negative_regulation (reduced) of Gene_expression (expression) of Tpl2 protein in macrophages
1) Confidence 0.31 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.75 Pain Relevance 0.11
Transfection of siRNA against Tpl2 achieved >80% efficiency in reducing endogenous Tpl2 protein levels (Fig. 4A).
Negative_regulation (reducing) of Gene_expression (levels) of Tpl2 protein
2) Confidence 0.31 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.22 Pain Relevance 0.25

General Comments

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