INT291214

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.20
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
adipocytes 2
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 195 99.86 Very High Very High Very High
Inflammation 130 99.66 Very High Very High Very High
Inflammatory stimuli 25 81.56 Quite High
Inflammatory mediators 10 46.48 Quite Low
tolerance 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 530 99.84 Very High Very High Very High
INFLAMMATION 165 99.66 Very High Very High Very High
Diabetes Mellitus 40 86.08 High High
Cancer 25 50.00 Quite Low
Necrosis 15 50.00 Quite Low
Insulin Resistance 50 14.56 Low Low
Hypertension 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 5 5.00 Very Low Very Low Very Low
Dislocations 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA in mice adipose tissues, we investigated whether these inflammatory cytokines could increase the expression of Tpl2 in adipocytes.
Positive_regulation (increase) of Gene_expression (expression) of Tpl2 in adipocytes associated with inflammation, obesity and cytokine
1) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.66 Pain Relevance 0.10
However, the results presented in Fig. 7E, and the observation that Tpl2 overexpression increases ERK1/2 activity (32), suggest that Tpl2 expression could be rate-limiting for the activation of ERK pathway.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Tpl2
2) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.64 Pain Relevance 0.14
-cells (34,35) but differs from MEF cells, in which Tpl2 is involved in both ERK1/2 and JNK activation (39).
Positive_regulation (activation) of Gene_expression (involved) of Tpl2
3) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.40 Pain Relevance 0.09
Tpl2 is involved in ERK1/2 activation specifically in response to IL-1?
Positive_regulation (activation) of Gene_expression (involved) of Tpl2
4) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.47 Pain Relevance 0.17
These results suggest that Tpl2 is involved in the lipolytic effect of IL-1?
Positive_regulation (effect) of Gene_expression (involved) of Tpl2
5) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.03 Pain Relevance 0.14

General Comments

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