INT291239

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) signal transduction (Map3k8) extracellular region (Mdk)
cell cycle (Map3k8) kinase activity (Map3k8) cytoplasm (Map3k8)
Anatomy Link Frequency
3T3-L1 1
adipocytes 1
Map3k8 (Mus musculus)
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 5 92.68 High High
cytokine 39 72.16 Quite High
Inflammatory mediators 2 57.60 Quite High
Inflammation 26 30.52 Quite Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 106 99.54 Very High Very High Very High
INFLAMMATION 33 92.36 High High
Cancer 5 50.00 Quite Low
Necrosis 3 50.00 Quite Low
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both 3T3-L1 and human adipocytes, we demonstrated that Tpl2 was involved in MEK/ERK1/2 activation in response to IL-1?
Tpl2 Regulation (involved) of in adipocytes Positive_regulation (activation) of MEK in 3T3-L1 associated with obesity
1) Confidence 0.08 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.53 Pain Relevance 0.11

General Comments

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