INT291252

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Map3k8, MAPK1) signal transduction (Map3k8, MAPK1) cell cycle (Map3k8, MAPK1)
nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
Map3k8 (Mus musculus)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 82.24 Quite High
cytokine 39 66.28 Quite High
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 106 87.56 High High
INFLAMMATION 33 82.24 Quite High
Diabetes Mellitus 8 52.32 Quite High
Cancer 5 50.00 Quite Low
Necrosis 3 50.00 Quite Low
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the results presented in Fig. 7E, and the observation that Tpl2 overexpression increases ERK1/2 activity (32), suggest that Tpl2 expression could be rate-limiting for the activation of ERK pathway.
Gene_expression (overexpression) of Tpl2 Positive_regulation (increases) of ERK1/2
1) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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