INT291257

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Map3k8, MAPK1) signal transduction (Map3k8, MAPK1) cell cycle (Map3k8, MAPK1)
nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
Anatomy Link Frequency
3T3-L1 1
adipocytes 1
Map3k8 (Mus musculus)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 10 92.68 High High
cytokine 78 89.96 High High
Inflammation 52 58.68 Quite High
Inflammatory mediators 4 57.60 Quite High
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 212 99.54 Very High Very High Very High
INFLAMMATION 66 92.36 High High
Diabetes Mellitus 16 53.92 Quite High
Cancer 10 50.00 Quite Low
Necrosis 6 50.00 Quite Low
Insulin Resistance 20 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both 3T3-L1 and human adipocytes, we demonstrated that Tpl2 was involved in MEK/ERK1/2 activation in response to IL-1?
Tpl2 Regulation (involved) of in adipocytes Positive_regulation (activation) of ERK1/2 in 3T3-L1 associated with obesity
1) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.53 Pain Relevance 0.11
Tpl2 is involved in ERK1/2 activation specifically in response to IL-1?
Tpl2 Regulation (involved) of Positive_regulation (activation) of ERK1/2
2) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.47 Pain Relevance 0.17

General Comments

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