INT291262

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.78
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) protein complex (Mapk1) cytoplasm (Mapk1)
INS (Homo sapiens)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 93.52 High High
Inflammation 52 85.48 High High
Inflammatory stimuli 10 82.96 Quite High
Inflammatory mediators 4 25.76 Quite Low
Kinase C 2 13.84 Low Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 212 96.40 Very High Very High Very High
Cancer 10 93.96 High High
INFLAMMATION 66 85.48 High High
Disease 2 59.16 Quite High
Insulin Resistance 20 56.88 Quite High
Metabolic Disorder 2 56.16 Quite High
Necrosis 6 50.00 Quite Low
Stress 2 32.92 Quite Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One important finding of our study is that Tpl2 was not required for the activation of ERK or PKB pathways by insulin.
Neg (not) Positive_regulation (required) of insulin Positive_regulation (activation) of ERK
1) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.76 Pain Relevance 0.29
, whereas it is dispensable for ERK activation by insulin.
Positive_regulation (dispensable) of insulin Positive_regulation (activation) of ERK
2) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.02 Pain Relevance 0.29

General Comments

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