INT291272

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IARS) nucleolus (IARS) nucleus (IARS)
ligase activity (IARS) cytoplasm (IARS)
Anatomy Link Frequency
brain 2
IARS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 1 73.76 Quite High
cocaine 1 69.64 Quite High
cytokine 1 43.80 Quite Low
vagus nerve 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Nucleus accumbens 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 14 93.76 High High
Aids-related Complex 4 67.44 Quite High
Appetite Loss 26 61.60 Quite High
Bronchopulmonary Dysplasia 2 37.92 Quite Low
Thinness 1 7.20 Low Low
Metabolic Syndrome 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low
Weight Gain 3 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obese individuals who have recently lost substantial amounts of weight became insulinresistant when put on a short-term hypercaloric diet, while lean individuals remained sensitive to insulin under identical circumstances.50 This phenomenon is explained, at least to some extent, by the ability of nutrient excess to block the activation of IRS/ PI 3-kinase signal transduction.51 Indeed, blunting of signal transduction by macronutrients has been observed in peripheral tissues as well as in brain tissue.29,52,53 Lastly, cumulating data have indicated that free fatty acids (FFAs) and glucose are each capable of increasing hepatic sensitivity to insulin and of reducing hepatic glucose production.
Negative_regulation (block) of Positive_regulation (activation) of IRS in brain associated with obesity
1) Confidence 0.04 Published 2007 Journal Obes Surg Section Body Doc Link PMC2798024 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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