INT291331

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSK3A, RAF1) mitochondrion (RAF1) carbohydrate metabolic process (GSK3A)
cytoplasm (RAF1) cell proliferation (RAF1) signal transduction (RAF1)
GSK3A (Homo sapiens)
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 88 100.00 Very High Very High Very High
Disease 9 65.00 Quite High
Cancer 34 60.80 Quite High
Toxicity 1 54.08 Quite High
Disease Progression 1 53.40 Quite High
Proteinuria 1 44.88 Quite Low
Hypertension 1 44.20 Quite Low
Fatigue 1 43.64 Quite Low
Manic Depressive Disorder 1 28.08 Quite Low
Metastasis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.
Negative_regulation (inactivation) of GSK-3 Positive_regulation (results) of Positive_regulation (activation) of Raf-1 associated with thyroid neoplasm
1) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.94 Pain Relevance 0

General Comments

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