INT291333

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CSHL1, NOTCH1) nucleoplasm (NOTCH1) Golgi apparatus (NOTCH1)
embryo development (NOTCH1) cytoplasm (NOTCH1) cytosol (NOTCH1)
Anatomy Link Frequency
nucleus 1
CSHL1 (Homo sapiens)
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 34 86.48 High High
Thyroid Neoplasm 88 81.28 Quite High
Manic Depressive Disorder 1 76.96 Quite High
Non-small-cell Lung Cancer 2 76.48 Quite High
Renal Cancer 1 72.64 Quite High
Apoptosis 2 59.84 Quite High
Lung Cancer 1 50.24 Quite High
Small Cell Lung Cancer 1 49.20 Quite Low
Carcinoid 1 48.64 Quite Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activated form of Notch1 then translocates to the nucleus and binds with the DNA-binding protein complex CSL (C promoter-binding factor 1, suppressor of hairless and Lag-1), resulting in transactivation of various target genes like hairy enhancer of split-1 (HES-1).
CSL Binding (binds) of Notch1 in nucleus
1) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.16 Pain Relevance 0

General Comments

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