INT291335

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.88 Pain Relevance 0

cytosol (RAF1, GSK3A) mitochondrion (RAF1) carbohydrate metabolic process (GSK3A) cytoplasm (RAF1) cell proliferation (RAF1) signal transduction (RAF1)

RAF1 (Homo sapiens) GSK3A (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 5.00 Somatostatin 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 88 100.00 Disease 9 65.00 Cancer 34 60.80 Toxicity 1 54.08 Disease Progression 1 53.40 Proteinuria 1 44.88 Hypertension 1 44.20 Fatigue 1 43.64 Manic Depressive Disorder 1 24.72 Metastasis 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.

Positive_regulation (activation) of Raf-1 Positive_regulation (results) of Phosphorylation (phosphorylation) of GSK-3 associated with thyroid neoplasm

1) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.88 Pain Relevance 0

General Comments

This test has worked.