INT291336

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 7.80
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 4
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 824 100.00 Very High Very High Very High
cytokine 64 92.16 High High
imagery 8 43.56 Quite Low
Inflammation 128 25.04 Quite Low
Immobilon 8 23.88 Low Low
Arthritis 64 5.00 Very Low Very Low Very Low
metalloproteinase 48 5.00 Very Low Very Low Very Low
rheumatoid arthritis 32 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 832 100.00 Very High Very High Very High
Targeted Disruption 24 100.00 Very High Very High Very High
Thyroid Neoplasm 264 99.68 Very High Very High Very High
Stress 8 96.12 Very High Very High Very High
Cancer 102 90.24 High High
Neuroblastoma 3 78.24 Quite High
Arthritis 72 39.60 Quite Low
Carcinoid 3 35.04 Quite Low
Small Cell Lung Cancer 3 34.56 Quite Low
Lung Cancer 3 34.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MKK3 and MKK6 and their relative contribution to the activation of p38-MAPK isoforms in OA has not been reported.
Gene_expression (Expression) of MKK6 associated with osteoarthritis
1) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.61 Pain Relevance 0.30
Transfection of human OA chondrocytes with MKK3 or MKK6-specific siRNAs knocked down the expression of target proteins and inhibited the IL-1?
Gene_expression (Transfection) of MKK6 in chondrocytes associated with osteoarthritis
2) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.08 Pain Relevance 0.45
-induced activation of p38-MAPK compared to the level noted in cells with knockdown expression of MKK6.
Gene_expression (expression) of MKK6
3) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.54 Pain Relevance 0.27
Human OA chondrocytes were transfected with human MKK3 or MKK6-specific siRNAs using On-Target SMART Pools (# L-00350900, L-00396700, Dharmacon RNA Technologies, Lafayette, CO, USA).
Gene_expression (transfected) of MKK6 in chondrocytes associated with osteoarthritis
4) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.22 Pain Relevance 0.11
Next, we investigated the effect of MKK3 or MKK6 knock down on the phosphorylation of p38-MAPK in response to stimulation with IL-1?
Gene_expression (knock) of MKK6 associated with targeted disruption
5) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.08 Pain Relevance 0.45
KK3 or MKK6 knockdown by transfection with small interfering RNAs (siRNA)
Gene_expression (knockdown) of MKK6
6) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.15 Pain Relevance 0.08
Expression and activation of MKK3 and MKK6 in human OA chondrocytes
Gene_expression (Expression) of MKK6 in chondrocytes associated with osteoarthritis
7) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.43 Pain Relevance 0.22
We then used these antibodies to determine the expression and phosphorylation of MKK3 and MKK6 proteins in human OA chondrocytes.
Spec (determine) Gene_expression (expression) of MKK6 in chondrocytes associated with osteoarthritis
8) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.51 Pain Relevance 0.25
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (The) of MEK
9) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.08 Pain Relevance 0
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (/) of MEK
10) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.01 Pain Relevance 0
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (/) of MEK
11) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.08 Pain Relevance 0

General Comments

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