INT291346

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL8, EGFR) nucleus (EGFR, GRB2) endosome (EGFR, GRB2)
Golgi apparatus (EGFR, GRB2) intracellular (IL8, EGFR) cytoplasm (EGFR, GRB2)
IL8 (Homo sapiens)
EGFR (Homo sapiens)
GRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 198 98.32 Very High Very High Very High
Inflammation 20 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 170 99.62 Very High Very High Very High
Cancer 312 89.00 High High
Pituitary Cancer 4 64.24 Quite High
Breast Cancer 20 51.60 Quite High
Apoptosis 4 43.24 Quite Low
Prostate Cancer 2 14.96 Low Low
Metastasis 36 5.00 Very Low Very Low Very Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 24 5.00 Very Low Very Low Very Low
Leukemia 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the ovarian cancer cell line SKOV-3, CXCL8/IL-8 was shown to induce transient phosphorylation of EGFR and its association with the adaptor molecules Shc and Grb2, suggests an important cross-talk between chemokine and growth factor pathways [39].
IL-8 Positive_regulation (induce) of EGFR Binding (association) of Grb2 associated with chemokine and ovarian cancer
1) Confidence 0.15 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.58 Pain Relevance 0.10
In the ovarian cancer cell line SKOV-3, CXCL8/IL-8 was shown to induce transient phosphorylation of EGFR and its association with the adaptor molecules Shc and Grb2, suggests an important cross-talk between chemokine and growth factor pathways [39].
CXCL8 Positive_regulation (induce) of EGFR Binding (association) of Grb2 associated with chemokine and ovarian cancer
2) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.58 Pain Relevance 0.10

General Comments

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