INT291349

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR4, EPHB2) cytoplasmic membrane-bounded vesicle (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
CXCR4 (Homo sapiens)
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 198 69.40 Quite High
antagonist 18 17.68 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 170 100.00 Very High Very High Very High
Cancer 312 95.36 Very High Very High Very High
Metastasis 36 94.24 High High
Disease 16 85.68 High High
Pituitary Cancer 4 84.44 Quite High
Pressure And Volume Under Development 18 83.84 Quite High
Disease Progression 2 72.80 Quite High
Malignant Neoplastic Disease 24 67.04 Quite High
Apoptosis 4 63.44 Quite High
INFLAMMATION 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies directly demonstrated that, in the presence of CXCL12, CXCR4 controls both ovarian cancer cell proliferation and migration, through the activation of the ERK1/2 and Akt pathway [40].
CXCR4 Positive_regulation (activation) of ERK1 associated with ovarian cancer
1) Confidence 0.42 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.27 Pain Relevance 0.03
More recently, several studies proposed that CXCR4-dependent activation of ERK1/2 was mediated by transactivation of tyrosine kinase receptors.
CXCR4-dependent Positive_regulation (activation) of ERK1
2) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.60 Pain Relevance 0.10

General Comments

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