INT291353

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL8, EGFR) extracellular space (IL8, EGFR) signal transduction (IL8, EGFR)
extracellular region (IL8, EGFR) endosome (EGFR) cell morphogenesis (EGFR)
IL8 (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 98.08 Very High Very High Very High
Inflammation 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 85 99.50 Very High Very High Very High
Cancer 156 88.76 High High
Pituitary Cancer 2 64.00 Quite High
Breast Cancer 10 48.40 Quite Low
Apoptosis 2 43.00 Quite Low
Prostate Cancer 1 11.76 Low Low
Metastasis 18 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 12 5.00 Very Low Very Low Very Low
Leukemia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the ovarian cancer cell line SKOV-3, CXCL8/IL-8 was shown to induce transient phosphorylation of EGFR and its association with the adaptor molecules Shc and Grb2, suggests an important cross-talk between chemokine and growth factor pathways [39].
IL-8 Positive_regulation (induce) of EGFR Binding (association) of associated with chemokine and ovarian cancer
1) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.52 Pain Relevance 0.10

General Comments

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