INT291354

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.02
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12) plasma membrane (EPHB2)
CXCL12 (Homo sapiens)
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 198 99.66 Very High Very High Very High
Central nervous system 8 34.04 Quite Low
antagonist 18 17.68 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 170 100.00 Very High Very High Very High
Cancer 312 97.40 Very High Very High Very High
Metastasis 36 94.56 High High
Apoptosis 4 93.36 High High
Disease 16 86.00 High High
Pressure And Volume Under Development 18 84.16 Quite High
Pituitary Cancer 4 78.56 Quite High
Disease Progression 2 73.12 Quite High
Malignant Neoplastic Disease 24 67.36 Quite High
Meningioma 2 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, beside survival, chemokines in general, and CXCL12 in particular, are also powerful activators of the MAP kinase (ERK1/2) cascade, the most studied proliferative mechanism responsible of tumor growth [30, 36].
CXCL12 Positive_regulation (activators) of ERK1 associated with chemokine and cancer
1) Confidence 0.42 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.75 Pain Relevance 0.12
In vitro studies directly demonstrated that, in the presence of CXCL12, CXCR4 controls both ovarian cancer cell proliferation and migration, through the activation of the ERK1/2 and Akt pathway [40].
CXCL12 Positive_regulation (activation) of ERK1 associated with ovarian cancer
2) Confidence 0.19 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.27 Pain Relevance 0.03

General Comments

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