INT291365

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 5.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
blood vessel 4
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 50.00 Quite Low
alcohol 1 35.88 Quite Low
antagonist 13 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 27 99.56 Very High Very High Very High
Carcinoma 246 99.46 Very High Very High Very High
Endometrial Cancer 615 98.76 Very High Very High Very High
Ovarian Cancer 85 98.52 Very High Very High Very High
Microsatellite Instability 188 98.28 Very High Very High Very High
Cancer 496 97.44 Very High Very High Very High
Endometroid Carcinoma 84 94.16 High High
Malignant Neoplastic Disease 84 75.12 Quite High
Metastasis 34 67.72 Quite High
Mucinous Adenocarcinoma 5 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PIK3CA mutations, particularly exon 20 mutations or PIK3CA mRNA overexpression, are frequent in endometrioid endometrial carcinoma in association with invasion and adverse prognostic factors such as blood vessel invasion [7, 15].

2.3.3.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PIK3CA in blood vessel associated with endometrial cancer
1) Confidence 0.41 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.21 Pain Relevance 0
However, PIK3CA mRNA overexpression occurs in concert with p53 alterations only in nonendometrioid endometrial carcinomas [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PIK3CA associated with endometrial cancer
2) Confidence 0.41 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.17 Pain Relevance 0
The tumors carrying exon 9 PIK3CA mutations are more likely to be low-grade carcinomas; in contrast, carcinomas with exon 20 mutations or PIK3CA mRNA overexpression are often high-grade carcinomas associated with myometrial invasion and tended to have lymphovascular invasion [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PIK3CA associated with cancer and carcinoma
3) Confidence 0.41 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.11 Pain Relevance 0
PIK3CA mutations, particularly exon 20 mutations or PIK3CA mRNA overexpression, are frequent in endometrioid endometrial carcinoma in association with invasion and adverse prognostic factors such as blood vessel invasion [7, 15].

2.3.3.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PIK3CA in blood vessel associated with endometrial cancer
4) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.24 Pain Relevance 0
Mutations, amplification, and overexpression of well-known oncogenes, such as PI3K subunit-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PI3K
5) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.03 Pain Relevance 0

General Comments

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