INT291366

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.64
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR7) plasma membrane (CXCR7) cytoplasm (CXCR7)
signal transducer activity (CXCR7)
Anatomy Link Frequency
leukocytes 1
neutrophil 1
CXCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 391 100.00 Very High Very High Very High
Inflammatory response 5 99.44 Very High Very High Very High
cytokine 11 90.92 High High
Inflammation 34 90.60 High High
Central nervous system 12 82.52 Quite High
Inflammatory stimuli 4 39.84 Quite Low
antagonist 27 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 47 99.26 Very High Very High Very High
Cancer 468 98.92 Very High Very High Very High
Meningioma 3 76.28 Quite High
Infection 64 76.00 Quite High
Pituitary Cancer 6 75.40 Quite High
Melanoma 15 74.40 Quite High
Glioblastoma 6 73.60 Quite High
Ovarian Cancer 255 72.80 Quite High
Solid Tumor 12 70.08 Quite High
Leukemia 30 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXC chemokines bind at least 7 receptors (CXCR1-7) and mediate neutrophil chemotaxis.
CXCR1-7 Binding (bind) of in neutrophil associated with chemokine
1) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.09 Pain Relevance 0.38
It was suggested that the key role of CXCR7 is to bind and internalize CXCL12 thereby controlling the level of the diffusible chemokine in the extracellular space [108].
CXCR7 Binding (bind) of associated with chemokine
2) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.11 Pain Relevance 0.09
The interaction of CXCL12 with CXCR4 mainly affects chemotaxis, while the binding to CXCR7 mediates proliferation in tumor cells [35].
CXCR7 Binding (binding) of associated with cancer
3) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.10 Pain Relevance 0.14
Chemokines were originally recognized for their ability to induce directed migration of leukocytes and facilitate controlled cellular accumulation and activation during an inflammatory response through receptor-dependent interactions between chemokines and their specific G-protein-coupled receptor(s) expressed by responsive cells [4].
G-protein-coupled receptor Binding (interactions) of in leukocytes associated with chemokine and inflammatory response
4) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.33 Pain Relevance 0.42

General Comments

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