INT291371

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.80
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
platelet 2
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 119 88.28 High High
antagonist 9 86.40 High High
cytokine 79 85.96 High High
Inflammation 50 85.60 High High
fibrosis 1 72.88 Quite High
Inflammatory response 3 8.84 Low Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 106 99.98 Very High Very High Very High
Herpes Simplex Virus 238 99.78 Very High Very High Very High
Ovarian Cancer 85 99.64 Very High Very High Very High
Cancer 176 99.08 Very High Very High Very High
Pressure And Volume Under Development 9 97.08 Very High Very High Very High
Metastasis 21 89.80 High High
INFLAMMATION 57 85.60 High High
Malignant Neoplastic Disease 16 73.52 Quite High
Fibrosis 1 72.88 Quite High
Breast Cancer 10 53.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, coculture experiments, using HPMCs and EOC, showed a strong increase in CXCL12 release, suggesting that some tumor-derived factors upregulate CXCL12 levels in ascites.
Positive_regulation (increase) of Localization (release) of CXCL12 associated with pressure and volume under development, cancer and ovarian cancer
1) Confidence 0.35 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.48 Pain Relevance 0.04
KSHV infection stimulated the secretion of growth factors and angiogenic factors such as insulin-like growth factor-1 (IGF-1), platelet derived growth factor-BB (PDGF-BB), macrophage colony stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), GM-CSF, angiogenin (Ang), oncostatin-M (Onco-M), TPO (thrombopoietin), VEGF, stromal cell-derived factor-1 (SDF-1), SCF (stem cell factor), TGF-?
Positive_regulation (stimulated) of Localization (secretion) of SDF-1 in platelet associated with herpes simplex virus and infection
2) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.32 Pain Relevance 0.61

General Comments

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