INT291377

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.57
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CX3CR1, Cx3cl1) plasma membrane (CX3CR1, Cx3cl1) extracellular space (Cx3cl1)
extracellular region (Cx3cl1) cytoplasm (Cx3cl1) signal transducer activity (CX3CR1)
Anatomy Link Frequency
anterior 2
T cell 1
CX3CR1 (Homo sapiens)
Cx3cl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 98.28 Very High Very High Very High
chemokine 145 97.84 Very High Very High Very High
rheumatoid arthritis 4 97.08 Very High Very High Very High
psoriasis 2 94.16 High High
Inflammatory stimuli 1 92.64 High High
Sicca syndrome 2 76.16 Quite High
cytokine 97 50.60 Quite High
Inflammatory mediators 9 41.20 Quite Low
antagonist 23 33.92 Quite Low
agonist 3 27.44 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 2 98.48 Very High Very High Very High
INFLAMMATION 59 98.28 Very High Very High Very High
Disease 52 97.76 Very High Very High Very High
Rheumatoid Arthritis 10 97.08 Very High Very High Very High
Asthma 4 96.20 Very High Very High Very High
Psoriasis 2 94.16 High High
Renal Disease 2 93.72 High High
Uveitis 2 91.96 High High
Increased Venous Pressure Under Development 2 91.08 High High
Eye Disease 130 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fractalkine/CX3CL1-CX3CR1 interaction contributes to the development of various inflammatory diseases such as rheumatoid arthritis, asthma, Wegener’s granulomatosis, Crohn’s disease, psoriasis, glomerulonephritis, experimental autoimmune anterior uveitis, and atherosclerosis [52-57].
CX3CR1 Binding (interaction) of CX3CL1 in anterior associated with psoriasis, renal disease, rheumatoid arthritis, increased venous pressure under development, disease, asthma, inflammation and uveitis
1) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.61 Pain Relevance 0.28
Fractalkine/CX3CL1-CX3CR1 interaction contributes to the development of various inflammatory diseases such as rheumatoid arthritis, asthma, Wegener’s granulomatosis, Crohn’s disease, psoriasis, glomerulonephritis, experimental autoimmune anterior uveitis, and atherosclerosis [52-57].
CX3CR1 Binding (interaction) of CX3CL1 in anterior associated with psoriasis, renal disease, rheumatoid arthritis, increased venous pressure under development, disease, asthma, inflammation and uveitis
2) Confidence 0.27 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.61 Pain Relevance 0.28
Lastly, the “CX3C” chemokines (three amino acids between the first two cysteines) are, to date, represented by a single peptide, namely, CX3CL1/fractalkine, which is encoded on human chromosome 16, binds the CX3CR1 receptor and regulates T cell trafficking and adhesion [4].
CX3CR1 receptor Binding (binds) of CX3C in T cell associated with chemokine and adhesions
3) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.34 Pain Relevance 0.46

General Comments

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