INT29138

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 10.06
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T-helper cell 8
spine 4
NK cells 4
cytotoxic T lymphocytes 4
T cells 4
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 472 100.00 Very High Very High Very High
Opioid 16 99.60 Very High Very High Very High
narcan 2 99.22 Very High Very High Very High
anesthesia 3 99.14 Very High Very High Very High
antagonist 15 99.04 Very High Very High Very High
opiate 7 98.82 Very High Very High Very High
spinal inflammation 3 97.16 Very High Very High Very High
Inflammation 293 97.04 Very High Very High Very High
Dynorphin 4 96.48 Very High Very High Very High
addiction 16 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 407 99.88 Very High Very High Very High
Necrosis 25 99.64 Very High Very High Very High
Disease Progression 4 98.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 232 98.36 Very High Very High Very High
Stress 34 97.28 Very High Very High Very High
Low Back Pain 7 97.16 Very High Very High Very High
INFLAMMATION 341 97.04 Very High Very High Very High
Multiple Sclerosis 25 90.72 High High
Disease 45 84.72 Quite High
Infection 70 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, an increase in the number of IL-2 secreting DCs in the PBMC preparations examined after the intervention, might explain the observed increase in IL-2 production in cultures derived from SMT-C and SMT-NC – treated subjects.
Spec (examined) Positive_regulation (increase) of Localization (secreting) of IL-2
1) Confidence 0.50 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.16 Pain Relevance 0
The results of the present study demonstrate clearly that manipulative intervention provided by spinal manipulation of the thoracic spine, results in a significant augmentation of IL-2 secretion in vitro induced by SPA.
Positive_regulation (augmentation) of Localization (secretion) of IL-2 in spine
2) Confidence 0.50 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Analysis of covariance of IL-2 secretion induced by the combination of TPA and ionophore revealed that at 20 minutes post-intervention there was no significant difference between the three groups (F = 2.59, p = 0.0846).
Positive_regulation (induced) of Localization (secretion) of IL-2
3) Confidence 0.46 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
A single HVLA manipulation to the thoracic spine of asymptomatic subjects causes a significant enhancement in IL-2 secretion by PBMCs in vitro.
Positive_regulation (enhancement) of Localization (secretion) of IL-2 in spine
4) Confidence 0.46 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.06 Pain Relevance 0.06
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (activation) of Localization (release) of interleukin-2 in T-helper cell associated with dynorphin, opioid and cytokine
5) Confidence 0.44 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.51 Pain Relevance 0.34
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (enhances) of Localization (release) of IL-2 in T-helper cell associated with dynorphin, opioid and cytokine
6) Confidence 0.44 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.50 Pain Relevance 0.34
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (activation) of Localization (release) of IL-2 in T-helper cell associated with dynorphin, opioid and cytokine
7) Confidence 0.44 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.51 Pain Relevance 0.34
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (enhances) of Localization (release) of interleukin-2 in T-helper cell associated with dynorphin, opioid and cytokine
8) Confidence 0.44 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.50 Pain Relevance 0.34
Besides the release of proinflammatory Th-1 cytokines, such as IFN-gamma and IL2 administration of melatonin to antigen-primed mice increased the production of IL10, indicating that melatonin can also activate anti-inflammatory Th-2-like immune responses in certain circumstances [128].
Positive_regulation (increased) of Localization (administration) of IL2 associated with inflammation and cytokine
9) Confidence 0.33 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.52 Pain Relevance 0.13
We examined the spontaneous secretion of interleukin 1 (IL-1) from peripheral blood monocytes and staphylococcal protein A (SPA) induced secretion of interleukin 2 (IL-2) from peripheral blood mononuclear cells from 13 patients with active ankylosing spondylitis and 10 healthy controls.
Positive_regulation (induced) of Localization (secretion) of IL-2 in blood associated with spinal inflammation
10) Confidence 0.30 Published 1986 Journal J. Rheumatol. Section Abstract Doc Link 3493347 Disease Relevance 0.30 Pain Relevance 0.17
HMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Positive_regulation (by) of Localization (lysis) of IL-2 in NK cells
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.07 Pain Relevance 0
HMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Positive_regulation (treated) of Localization (lysis) of IL-2 in NK cells
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.07 Pain Relevance 0
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Positive_regulation (up) of Localization (secretion) of IL-2 associated with anesthesia and cytokine
13) Confidence 0.14 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.12 Pain Relevance 0.32
These data show that MVA-CMDR was immunogenic eliciting predominantly CD4+ responses as measured by IL-2 and IFN?
Positive_regulation (by) of Localization (measured) of IL-2
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.11 Pain Relevance 0.17
No significant variations in the secretion of IL-2 or IL-10 were observed (data not shown).
Neg (No) Positive_regulation (variations) of Localization (secretion) of IL-2
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.27 Pain Relevance 0
In a second phase, cortisol enhances the recruitment of T-helper-2 cells, and subsequently released cytokines such as IL-2, IL-4 and IL-13 stimulate 11?
Positive_regulation (stimulate) of Localization (released) of IL-2 associated with cytokine
16) Confidence 0.10 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.48 Pain Relevance 0.29
On the basis of these results, IL-2 release was
Positive_regulation (was) of Localization (release) of IL-2
17) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.20 Pain Relevance 0.44
Andrographolide enhances secretion of IL-2 and IFN?
Positive_regulation (enhances) of Localization (secretion) of IL-2
18) Confidence 0.07 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.61 Pain Relevance 0.04
On the other hand, when murine T cell is stimulated with mitogen, IL-2 was decreased by andrographolide [66] possibly via reducing nuclear factor of activated T cells (NFAT) activities and increasing JNK phosphorylation [67].
Positive_regulation (increasing) of Localization (decreased) of IL-2 in T cells
19) Confidence 0.05 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.90 Pain Relevance 0.07
Sheeja et al. showed that the A. paniculata ethanol extract and andrographolide stimulated the cytotoxic T lymphocytes (CTL) activity through enhanced release of IL-2 and IFN?
Positive_regulation (stimulated) of Localization (release) of IL-2 in cytotoxic T lymphocytes
20) Confidence 0.05 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.04 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox