INT291394

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
neuronal 3
HTT (Homo sapiens)
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 40 97.26 Very High Very High Very High
Glutamate receptor 6 33.84 Quite Low
nMDA receptor 6 31.64 Quite Low
cytokine 4 21.44 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.84 Very High Very High Very High
Disease 12 99.58 Very High Very High Very High
Stress 1 93.52 High High
Sclerosis 1 92.80 High High
Neurodegenerative Disease 3 90.08 High High
Neurological Disease 1 54.08 Quite High
Leukemia 1 12.20 Low Low
Death 1 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, glutamate uptake inhibition in the rat striatum has been shown to trigger massive neuronal loss [35] mimicking excitotoxic HD models [3], and the expression of a mutant form of huntingtin decreases GLT-1 expression in transgenic HD mice [36] and in patients [34].
Gene_expression (expression) of huntingtin in neuronal Negative_regulation (decreases) of Gene_expression (expression) of GLT-1 in neuronal associated with targeted disruption, glutamate and disease
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.96 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox