INT291431

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnn2)
Anatomy Link Frequency
pyramidal neurons 2
spines 2
Kcnn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 60 99.68 Very High Very High Very High
long-term potentiation 24 98.86 Very High Very High Very High
Hippocampus 12 83.76 Quite High
nMDA receptor 27 69.44 Quite High
Glutamate receptor 6 54.80 Quite High
potassium channel 9 50.00 Quite Low
monoamine 3 31.72 Quite Low
Neurotransmitter 6 29.92 Quite Low
Neuronal excitability 9 28.92 Quite Low
amygdala 15 6.00 Low Low
Disease Link Frequency Relevance Heat
Schizophrenia 42 91.84 High High
Manic Depressive Disorder 12 68.32 Quite High
Disease 24 22.28 Low Low
Anorexia 9 7.84 Low Low
Anxiety Disorder 3 7.44 Low Low
Ataxia 24 5.00 Very Low Very Low Very Low
Epilepsy 18 5.00 Very Low Very Low Very Low
Headache 15 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This truncated protein was shown to have a nuclear localization and suppress the expression of SK2-mediated currents in Jurkat cells [232].
Negative_regulation (suppress) of Gene_expression (expression) of SK2
1) Confidence 0.42 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.73 Pain Relevance 0
Taken together, these findings suggest that BDNF might facilitate the induction of LTP by inhibiting SK-mediated currents possibly through the reduction of SK2 surface expression in CA1 pyramidal neurons [96, 117].
Negative_regulation (reduction) of Gene_expression (expression) of SK2 in pyramidal neurons associated with pyramidal cell and long-term potentiation
2) Confidence 0.36 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.26
The reduction in the surface expression of SK2 channels in dendritic spines and consequent potentiation of NMDA-mediated currents, together with the increase in AMPA receptor surface expression, would contribute the synaptic strengthening underlying LTP induction in CA1 neurons [84].
Negative_regulation (reduction) of Gene_expression (expression) of SK2 in spines associated with long-term potentiation
3) Confidence 0.31 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox