INT29144

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Context Info
Confidence 0.52
First Reported 1987
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 41
Total Number 46
Disease Relevance 29.23
Pain Relevance 47.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 15
neurons 8
spinal cord 2
amygdala 2
dorsal 1
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 996 100.00 Very High Very High Very High
Periaqueductal grey 156 100.00 Very High Very High Very High
Antinociceptive 92 100.00 Very High Very High Very High
mu opioid receptor 85 100.00 Very High Very High Very High
medulla 73 100.00 Very High Very High Very High
amygdala 23 100.00 Very High Very High Very High
Rostroventromedial medulla 23 100.00 Very High Very High Very High
midbrain 14 100.00 Very High Very High Very High
Raphe magnus 9 100.00 Very High Very High Very High
agonist 23 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 670 100.00 Very High Very High Very High
Nervous System Injury 383 99.96 Very High Very High Very High
Hypoalagesia 9 99.84 Very High Very High Very High
Neuroleptic Malignant Syndrome 36 99.68 Very High Very High Very High
Hyperalgesia 173 99.32 Very High Very High Very High
Neuropathic Pain 249 99.24 Very High Very High Very High
Pain 434 98.96 Very High Very High Very High
Hypersensitivity 59 98.92 Very High Very High Very High
INFLAMMATION 160 98.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the activation of RVM ON-cells produced by a noxious stimulus is sufficient to enhance some nocifensor reflexes, whereas neural structures other than the RVM appear to mediate the antinociceptive effects produced by a prolonged noxious stimulus.
Gene_expression (produced) of RVM in RVM associated with antinociceptive and rostral ventromedial medulla
1) Confidence 0.52 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807201 Disease Relevance 0.14 Pain Relevance 0.69
Inflammation-induced microglial and astrocytic activation in the RVM were attenuated by RVM microinjection of the glial inhibitors.
Gene_expression (microinjection) of RVM in RVM associated with rostroventromedial medulla and inflammation
2) Confidence 0.51 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.93 Pain Relevance 1.39
In some experiments, microinjection of lidocaine (0.5 microl of 4% solution) or the neurotoxin ibotenic acid (0.5 microl, 10 microg) into the RVM produced reversible or long-lasting, respectively, decreases in spontaneous activity and responses of spinal neurons to CRD.
Gene_expression (produced) of RVM in RVM associated with medulla and lidocaine
3) Confidence 0.51 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11976363 Disease Relevance 0.16 Pain Relevance 0.53
At 38 other sites in the RVM, electrical stimulation produced only intensity-dependent inhibition of neuron responses to CRD.
Gene_expression (produced) of RVM in neuron associated with medulla
4) Confidence 0.51 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11976363 Disease Relevance 0.07 Pain Relevance 0.26
In uninjured rats, RVM microinjection of morphine produced dose-dependent antinociception in the noxious thermal paw flick test while RVM microinjection of CCK produced thermal hyperalgesia and tactile allodynia.
Gene_expression (microinjection) of RVM in paw associated with brush evoked pain, antinociception, rostroventromedial medulla, thermal hyperalgesia and morphine
5) Confidence 0.43 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427839 Disease Relevance 0.76 Pain Relevance 1.86
Paw withdrawal responses were obtained before and after RVM injection, and then at 5, 30, and 60 min after an intraplantar injection of capsaicin (10 microg).
Gene_expression (injection) of RVM in RVM associated with qutenza, withdrawal and rostral ventromedial medulla
6) Confidence 0.43 Published 2008 Journal Pain Section Abstract Doc Link 18407414 Disease Relevance 0.44 Pain Relevance 1.53
In the voltage-clamp mode, the RVM glutamate injection and RVM-ES produced an increase in both the frequency and amplitude of IPSCs in SG neurons that was not blocked by glutamate receptor antagonists.
Gene_expression (produced) of RVM-ES in neurons associated with substantia gelatinosa, glutamate, antagonist, glutamate receptor and rostral ventromedial medulla
7) Confidence 0.38 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16467527 Disease Relevance 0.08 Pain Relevance 1.21
In six male Wistar-Kyoto rats (WKY), unilateral injection of an antisense oligonucleotide to c-fos mRNA suppressed the expression of Fos-like immunoreactivity in neurons in the RVM in response to inhibition of depressor neurons in the caudal ventrolateral medulla (CVLM).
Gene_expression (expression) of RVM in medulla associated with medulla
8) Confidence 0.38 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8184987 Disease Relevance 0 Pain Relevance 0.44
These studies demonstrate that expression of c-fos in the RVM can be blocked in vivo by treatment with an antisense oligonucleotide, and that basal and stimulated expression of the c-fos gene is important in the central control of arterial blood pressure.
Gene_expression (expression) of RVM in blood associated with medulla
9) Confidence 0.38 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8184987 Disease Relevance 0 Pain Relevance 0.42
The intra-RVM microinjection with dermorphin-saporin could specifically abolish this facilitation in rodent models by selectively ablating the RVM neurons expressing mu opioid receptors.
Gene_expression (expressing) of RVM in neurons associated with mu opioid receptor and rostral ventromedial medulla
10) Confidence 0.34 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19559047 Disease Relevance 0.32 Pain Relevance 0.62
In opioid-naive rats, CCK in the RVM produced acute tactile and thermal hypersensitivity that was antagonized by the CCK2 receptor antagonist L365,260 or by DLF lesion.
Gene_expression (produced) of RVM in DLF associated with antagonist, hypersensitivity, cholecystokinin, opioid and rostral ventromedial medulla
11) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647484 Disease Relevance 0.66 Pain Relevance 2.01
To determine how KOR agonists produce both antinociceptive and antianalgesic actions within the RVM, the KOR agonist U69593 was microinjected directly into the RVM while concurrently monitoring tail flick latencies and RVM neuronal activity.
Spec (determine) Gene_expression (produce) of RVM in RVM associated with tail-flick, agonist, kappa opioid receptor, antinociceptive and rostral ventromedial medulla
12) Confidence 0.32 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15456805 Disease Relevance 0.17 Pain Relevance 1.62
The other 2 groups of animals were dedicated to histochemical analysis of pERK expression in the RVM: animals underwent SNI or sham surgery and were perfused on day 3 or on day 8 post-surgery.
Gene_expression (expression) of RVM associated with nervous system injury and rostral ventromedial medulla
13) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.60 Pain Relevance 0.26
In our study, 8 days post SNI surgery, pERK expression within the RVM was limited to neurons and no glial activation was seen. p38, another MAPK involved in the maintenance of pain states, was found in microglia in the RVM 3 h after carrageenan injection into the hindpaw [27].
Gene_expression (expression) of RVM in microglia associated with pain, nervous system injury, glial activation and rostral ventromedial medulla
14) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.28 Pain Relevance 0.84
Mechanical thresholds were measured for another 7 days and on day 8 animals were perfused for histochemical analysis of pERK expression in the RVM.
Gene_expression (expression) of RVM associated with rostral ventromedial medulla
15) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.94 Pain Relevance 0.67
These data imply that NMDA receptors and nitric oxide production in the RVM modulate the transmission of opioid pain-inhibitory signals from the PAG.
Gene_expression (production) of RVM in RVM associated with pain, periaqueductal grey, nmda receptor, opioid and rostral ventromedial medulla
16) Confidence 0.27 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16026519 Disease Relevance 0.64 Pain Relevance 1.72
Thus, lesions in the medulla or spinal cord that affect descending projections from the RVM as well as opioid antagonists delivered into the RVM diminish the effects of systemic morphine [21].
Gene_expression (projections) of RVM in spinal cord associated with medulla, antagonist, opioid, morphine, rostral ventromedial medulla and spinal cord
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.94 Pain Relevance 2.34
The rostral ventromedial medulla (RVM) which includes the nucleus raphe magnus and the laterally adjacent reticular formation is the major relay of midbrain PAG neurons that project down to the substantia gelatinosa in the dorsal horn of the spinal cord.
Gene_expression (neurons) of RVM in neurons associated with substantia gelatinosa, raphe magnus, periaqueductal grey, dorsal horn, midbrain, spinal cord and rostral ventromedial medulla
18) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.57 Pain Relevance 2.04
P10 rats do not develop neuropathic pain and do not show any increase in pERK expression in the RVM following SNI
Gene_expression (following) of RVM associated with nervous system injury, neuropathic pain and rostral ventromedial medulla
19) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.99 Pain Relevance 0.49
It seems likely that primary afferent activity following SNI is of particular importance in inducing the neuropathic pain state but that maintenance requires pERK activity in RVM neurons.
Gene_expression (neurons) of RVM in neurons associated with nervous system injury, neuropathic pain and rostral ventromedial medulla
20) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.76 Pain Relevance 1.15

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