INT291449

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
hippocampus 1
Car2 (Mus musculus)
SK (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 8 93.28 High High
Hippocampus 4 91.44 High High
Pyramidal cell 20 85.28 High High
nMDA receptor 9 80.60 Quite High
amygdala 5 76.32 Quite High
potassium channel 3 50.00 Quite Low
Glutamate 3 46.04 Quite Low
Action potential 20 21.56 Low Low
Calcium channel 2 10.60 Low Low
Ventral tegmentum 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 24.64 Low Low
Schizophrenia 14 5.00 Very Low Very Low Very Low
Ataxia 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Headache 5 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 4 5.00 Very Low Very Low Very Low
Anorexia 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the importance of Ca2+ transients in dendritic spines for the induction of synaptic plasticity [106, 107], these negative feedback systems, where Ca2+ entering the cell activates SK channels, which in turn shut the sources of Ca2+ entry, might explain the role of SK channels and the effects of apamin in lowering the threshold for the induction of long-term potentiation (LTP) and facilitating hippocampus-dependent learning and memory processes [108–111].
Ca2 Positive_regulation (activates) of SK in hippocampus associated with hippocampus and long-term potentiation
1) Confidence 0.03 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.39

General Comments

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