INT291450

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
neurons 4
Kcnn3 (Mus musculus)
SK (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 40 79.44 Quite High
potassium channel 6 50.00 Quite Low
Thalamus 2 47.40 Quite Low
Substantia nigra 14 21.36 Low Low
Pyramidal cell 40 5.00 Very Low Very Low Very Low
Ventral tegmentum 20 5.00 Very Low Very Low Very Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
long-term potentiation 16 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
amygdala 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 98.96 Very High Very High Very High
Ataxia 16 66.24 Quite High
Schizophrenia 28 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Epilepsy 12 5.00 Very Low Very Low Very Low
Headache 10 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 8 5.00 Very Low Very Low Very Low
Anorexia 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Generalized Epilepsy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The impact of SK channels on the function of DCN neurons has been further corroborated by experiments performed on transgenic mice expressing a dominant negative variant of the SK3 subunit (SK3-1B, [24]) that suppresses the expression of all SK channel subtypes.
SK3 subunit Negative_regulation (suppresses) of Gene_expression (expression) of SK in neurons associated with targeted disruption
1) Confidence 0.10 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.26 Pain Relevance 0.04
The impact of SK channels on the function of DCN neurons has been further corroborated by experiments performed on transgenic mice expressing a dominant negative variant of the SK3 subunit (SK3-1B, [24]) that suppresses the expression of all SK channel subtypes.
SK3-1B Negative_regulation (suppresses) of Gene_expression (expression) of SK in neurons associated with targeted disruption
2) Confidence 0.10 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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