INT291467

Context Info Confidence 0.53 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.87 Pain Relevance 0.07

endoplasmic reticulum (Hcrt) plasma membrane (Hcrtr1) signal transducer activity (Hcrtr1) cytoplasm (Hcrt)

Hcrt (Mus musculus) Hcrtr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tolerance 4 67.36 Central nervous system 2 5.00 Spinal cord 2 5.00 anesthesia 2 5.00 Locus ceruleus 2 5.00 amygdala 2 5.00 Neurotransmitter 2 5.00 Hippocampus 2 5.00 Raphe 2 5.00

Disease Link Frequency Relevance Heat Obesity 8 99.76 Hyperphagia 2 99.28 Sleep Disorders 2 98.76 Diabetes Mellitus 222 71.60 Impaired Glucose Tolerance 4 67.36 Apoptosis 44 5.00 Targeted Disruption 16 5.00 Stress 8 5.00 Ganglion Cysts 6 5.00 Body Weight 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Orexin-1 receptor (OX1R) was the first of the two orexin receptors to be discovered and binds orexin-A with a much higher affinity compared to orexin B.

orexin-A Binding (binds) of OX1R

1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.43 Pain Relevance 0.03

Orexin-1 receptor (OX1R) was the first of the two orexin receptors to be discovered and binds orexin-A with a much higher affinity compared to orexin B.

orexin-A Binding (binds) of Orexin-1 receptor

2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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