INT291556

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.86 Pain Relevance 0.50

nucleoplasm (ESR1) Golgi apparatus (Sec22b) endoplasmic reticulum (Sec22b) enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1)

ESR1 (Homo sapiens) Sec22b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 1 98.96 agonist 18 98.80 antagonist 5 98.32 ischemia 54 96.00 Hippocampus 9 92.04 Bioavailability 8 89.12 cva 9 60.48 Pyramidal cell 22 5.00 withdrawal 8 5.00 Neuronal excitability 5 5.00

Disease Link Frequency Relevance Heat Osteoporosis 41 96.60 Cv Unclassified Under Development 52 96.00 Cv General 4 Under Development 1 91.28 Stress 1 88.68 Polyps 2 66.96 Reprotox - General 1 10 65.76 Aging 7 62.32 Cramps 3 61.12 Pulmonary Embolism 2 60.48 Deep Vein Thrombosis 7 59.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

During the past 10 years, several efforts have been devoted to the understanding of ER system and the development of compounds that interact with intracellular ERs in target organs as estrogen agonist and antagonists.

ER Binding (interact) of ERs associated with antagonist and agonist

1) Confidence 0.00 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.41 Pain Relevance 0.17

Tamoxifen affords neuroprotection through its anti-oxidant properties without interacting directly with ERs [9] or by activating ER-?

ER Binding (interacting) of ERs

2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.45 Pain Relevance 0.33

General Comments

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