INT291556

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) Golgi apparatus (Sec22b) endoplasmic reticulum (Sec22b)
enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1)
ESR1 (Homo sapiens)
Sec22b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 98.96 Very High Very High Very High
agonist 18 98.80 Very High Very High Very High
antagonist 5 98.32 Very High Very High Very High
ischemia 54 96.00 Very High Very High Very High
Hippocampus 9 92.04 High High
Bioavailability 8 89.12 High High
cva 9 60.48 Quite High
Pyramidal cell 22 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
Neuronal excitability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 41 96.60 Very High Very High Very High
Cv Unclassified Under Development 52 96.00 Very High Very High Very High
Cv General 4 Under Development 1 91.28 High High
Stress 1 88.68 High High
Polyps 2 66.96 Quite High
Reprotox - General 1 10 65.76 Quite High
Aging 7 62.32 Quite High
Cramps 3 61.12 Quite High
Pulmonary Embolism 2 60.48 Quite High
Deep Vein Thrombosis 7 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the past 10 years, several efforts have been devoted to the understanding of ER system and the development of compounds that interact with intracellular ERs in target organs as estrogen agonist and antagonists.
ER Binding (interact) of ERs associated with antagonist and agonist
1) Confidence 0.00 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.41 Pain Relevance 0.17
Tamoxifen affords neuroprotection through its anti-oxidant properties without interacting directly with ERs [9] or by activating ER-?
ER Binding (interacting) of ERs
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.45 Pain Relevance 0.33

General Comments

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