INT291581

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) mitochondrion (Abat) signal transduction (Pde5a)
Anatomy Link Frequency
granule cells 2
Pde5a (Rattus norvegicus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 11 100.00 Very High Very High Very High
Pyramidal cell 1 99.54 Very High Very High Very High
Neurotransmitter 1 95.54 Very High Very High Very High
Hippocampus 1 94.62 High High
Antinociceptive 5 81.36 Quite High
antagonist 13 79.80 Quite High
antinociception 10 74.56 Quite High
potassium channel 3 63.44 Quite High
Pain 4 50.00 Quite Low
Neuropathic pain 19 46.16 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 29 50.00 Quite Low
Hyperalgesia 6 12.68 Low Low
Increased Venous Pressure Under Development 2 8.48 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Post Operative Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hippocampus, GABA is the main inhibitory neurotransmitter, modulated by inhibitory GABA-releasing interneurons.29,30 GABA is thought to be released from the interneurons upon feed-forward inhibition by granule cells or feedback inhibition by pyramidal cells.31 On the other hand, cGMP appears to be involved in GABA release, having effects of its own as well as a part of the nitric oxide-cGMP pathway.
cGMP Spec (appears) Regulation (involved) of Localization (release) of GABA in granule cells associated with neurotransmitter, gaba, pyramidal cell and hippocampus
1) Confidence 0.03 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 0 Pain Relevance 0.83

General Comments

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