INT291583

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
GUCY2C (Homo sapiens)
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 10 90.80 High High
Analgesic 1 87.92 High High
Neuropathic pain 19 84.36 Quite High
Hyperalgesia 5 83.32 Quite High
allodynia 7 81.76 Quite High
Cold hyperalgesia 1 80.88 Quite High
Pain 4 75.64 Quite High
Spontaneous pain 1 72.84 Quite High
Central nervous system 1 68.96 Quite High
gABA 11 50.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 29 84.36 Quite High
Hyperalgesia 6 83.32 Quite High
Pain 3 75.64 Quite High
Disease 2 67.20 Quite High
Injury 3 66.72 Quite High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Post Operative Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Guanylyl cyclase catalyzes the formation of cyclic guanosine monophosphate (cGMP) from GTP, leading to the synthesis of cGMP, whereas cGMP-specific phosphodiesterase catalyzes the hydrolysis of cGMP to GMP.2 Accordingly, intracellular cGMP concentrations are regulated by the action of guanylyl cyclase and the rate of degradation by cGMP-specific phosphodiesterase.6,7
guanylyl cyclase Regulation (regulated) of cGMP
1) Confidence 0.00 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 1.12 Pain Relevance 1.45

General Comments

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