INT291617

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
mesangial cells 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 98.66 Very High Very High Very High
anesthesia 7 88.72 High High
epidural 1 88.28 High High
Inflammation 21 87.04 High High
Inflammatory response 5 80.72 Quite High
addiction 12 72.32 Quite High
cytokine 4 63.76 Quite High
antagonist 4 50.00 Quite Low
fibrosis 31 47.12 Quite Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 87.04 High High
Systemic Inflammatory Response Syndrome 22 84.00 Quite High
Fibrosis 33 81.24 Quite High
Sclerosis 2 67.40 Quite High
Adult Respiratory Distress Syndrome 20 62.08 Quite High
Esophageal Cancer 13 50.00 Quite Low
Ureteral Obstruction 16 34.16 Quite Low
Renal Disease 8 31.44 Quite Low
Chronic Renal Failure 2 25.44 Quite Low
Internal Fibrosis 1 17.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Negative_regulation (measured) of Transcription (levels) of TGF
1) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.37 Pain Relevance 0.50
agonists inhibited the Smad signaling pathway in the renal fibroblasts and blocked TGF-beta/Smad-mediated gene transcription in mesangial cells (22).
Negative_regulation (blocked) of Transcription (transcription) of TGF-beta in mesangial cells associated with agonist
2) Confidence 0.05 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.24 Pain Relevance 0.26

General Comments

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