INT291667

Context Info Confidence 0.22 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.28

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Anatomy Link Frequency myocardial cells 2 Alox5 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 5 98.86 ischemia 2 84.76 Central nervous system 10 76.28 depression 2 58.72 cerebral cortex 2 49.04 Hippocampus 9 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 98.86 Cv Unclassified Under Development 1 84.76 Disease 1 83.32 Brain Hemorrhage 1 79.84 Aging 39 78.60 Depression 2 58.72 Neurodegenerative Disease 1 50.96 Increased Venous Pressure Under Development 1 42.52 Lifespan 1 21.68 Urological Neuroanatomy 5 5.00

Sentences Mentioned In

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Protein

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Event

Anatomy

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Furthermore, in the heart, that is, myocardial cells, drugs such as statins and thiazolidinediones trigger anti-inflammatory processes and increase the production of anti-inflammatory lipoxins depending on 5-LOX, particularly the status of 5-LOX phosphorylation [15, 23]. 5-LOX gene expression is regulated by epigenetic mechanisms including modifications of DNA methylation [1, 24–26].

Regulation (regulated) of Phosphorylation (phosphorylation) of 5-LOX in myocardial cells associated with inflammation

1) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.63 Pain Relevance 0.28

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