INT291677

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 3.91
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
heart 5
brain 1
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 90 83.68 Quite High
Hippocampus 81 82.96 Quite High
cerebral cortex 18 70.24 Quite High
depression 18 67.08 Quite High
Inflammation 45 26.52 Quite Low
ischemia 18 13.56 Low Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 351 99.50 Very High Very High Very High
Urological Neuroanatomy 45 96.88 Very High Very High Very High
Brain Disease 9 90.88 High High
Coronary Artery Disease 9 83.80 Quite High
Lifespan 9 71.20 Quite High
Depression 18 67.08 Quite High
INFLAMMATION 45 26.52 Quite Low
Cv Unclassified Under Development 9 13.56 Low Low
Disease 9 12.12 Low Low
Brain Hemorrhage 9 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results

Figure 3 shows that the expression levels of 5-LOX mRNA in heart tissue are about fifty times greater than in brain tissue.

Transcription (levels) of 5-LOX in heart
1) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.26 Pain Relevance 0
Inherent in studies with tissue samples as opposed to research in cell cultures is that 5-LOX DNA extracted from tissue samples derives from both 5-LOX mRNA-expressing and mRNA-nonexpressing cells.
Transcription (expressing) of 5-LOX
2) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.12 Pain Relevance 0.09
It has to be stressed that our results were obtained in tissue samples containing a mixture of various cell types and that further insight into functional implications of DNA methylation for 5-LOX mRNA expression would require cell-type directed studies.
Transcription (expression) of 5-LOX
3) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.37 Pain Relevance 0.17
In line with previous reports [14], we confirmed that 5-LOX mRNA is expressed in the mouse brain, albeit at levels significantly lower than 5-LOX mRNA levels measured in heart tissue.
Transcription (expressed) of 5-LOX in heart
4) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.72 Pain Relevance 0.17
Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.
Transcription (levels) of 5-LOX in heart associated with aging
5) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.46 Pain Relevance 0.14
In line with previous reports [14], we confirmed that 5-LOX mRNA is expressed in the mouse brain, albeit at levels significantly lower than 5-LOX mRNA levels measured in heart tissue.
Transcription (levels) of 5-LOX in heart
6) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.74 Pain Relevance 0.18
However, in the heart, aging resulted in significantly decreased 5-LOX mRNA levels (Figure 3).
Transcription (levels) of 5-LOX in heart associated with aging
7) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.40 Pain Relevance 0.03
Further research is needed to elucidate if the observed changes in 5-LOX DNA methylation could play a role in aging-associated modifications of tissue 5-LOX mRNA levels.
Transcription (levels) of 5-LOX associated with aging
8) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.39 Pain Relevance 0
Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.
Transcription (levels) of 5-LOX in brain associated with aging
9) Confidence 0.17 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.46 Pain Relevance 0.14

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