INT291679

Context Info Confidence 0.25 First Reported 2009 Last Reported 2009 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.94 Pain Relevance 0.28

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Anatomy Link Frequency heart 3 brain 1 Alox5 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 20 83.68 cerebral cortex 4 71.20 Inflammation 10 27.48 ischemia 4 14.52 Hippocampus 18 5.00 depression 4 5.00 ketamine 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Aging 78 99.98 Brain Disease 2 91.84 Coronary Artery Disease 2 84.76 Lifespan 2 72.16 INFLAMMATION 10 27.48 Cv Unclassified Under Development 2 14.52 Disease 2 13.08 Brain Hemorrhage 2 9.60 Urological Neuroanatomy 10 5.00 Depression 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.

Spec (whether) Regulation (affects) of Transcription (levels) of 5-LOX in heart associated with aging

1) Confidence 0.25 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.47 Pain Relevance 0.14

Here, we investigated whether aging affects brain and heart 5-LOX mRNA levels and DNA methylation.

Spec (whether) Regulation (affects) of in brain Transcription (levels) of 5-LOX in heart associated with aging

2) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.47 Pain Relevance 0.14

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